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| Influence of different doses of melatonin for treating patients with laparoscopic hysterectomy under general anesthesia on their postoperative pain, sleep, and inflammation indicators |
| Xuancheng People's Hospital, Xuancheng, Anhui Province, 242000 |
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Abstract To investigate the influence of different doses of melatonin for treating patients with laparoscopic hysterectomy under general anesthesia on their postoperative pain, sleep, and inflammation indicators. Methods: A total of 96 patients who wanted laparoscopic hysterectomy under general anesthesia were selected and were randomly divided into group A(48 cases with 5 mg melatonin treatment before operation) and group B(48 cases with 10 mg melatonin treatment before operation). The sleep quality evaluated by St.Mary's Hospital Sleep Questionnaire(SMH) and Pittsburgh Sleep Quality Index(PSQI), the alleviate situation of pain evaluated by Visual Analogue Scale(VAS) and Numerical Rating Scale(NRS), the levels of inflammatory indicators, such as tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), and C-reactive protein(CRP), the serum central nervous system specific protein(S100-β) level, the cognitive function evaluated by MiniMental State Examination(MMSE), and the rate of adverse reactions of the patients were compared between the two groups. Results: The SMH score and MMSE score of the patients in the two groups on the 1st day after operation were significantly lower than those 1 day before operation, but which of the patients in group B were significantly higher than those of the patients in group A. The SMH score and MMSE score the patients in the two groups on the 7th day after operation were significantly higher than those on the 1st day after operation(P<0.05), but which of the patients had no significant difference between the two groups. The PSQI score of the patients in the two groups on the 1st day after operation was significantly higher than that 1 day before operation, and which of the patients in group B was significantly lower than that of the patients in group A(P<0.05). The PSQI scores of the patients in the two groups on the 7th day after operation were significantly lower than that on the 1st day after operation(P< 0.05), but which of the patients had no significant difference between the groups. The VAS and NRS scores of the patients in group B on the 1st, the 2 second, and the 3rd day after operation were significantly lower than those of the patients in group A. The serum levels of TNF-α, IL-6, and CRP the patients in the two groups on the 1st day after operation were significantly higher than those before operation, and which of the patients in group B were significantly lower than those of the patients in group A. The serum S100β level of the patients in the two groups on the 1st day after operation were significantly higher than that before operation, and the increase degree of the patients in group B was significantly lower than that of the patients in group A(all P< 0.05). There were no any patients with adverse reactions, such as pruritus, reflux aspiration, respiratory depression, hypoxemia, nausea, or vomiting in the two groups. Conclusion: Compared with those of 5mg melatonin, 10mg melatonin for treating the patients before laparoscopic hysterectomy under general anesthesia can more effectively reduce the inflammation and pain of the patients, reduce the changes of their postoperative cognitive function and sleep quality, with medication safety.
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