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| Analysis of clinicopathological feature of the asymptomatic endometrial thickening of postmenopausal women |
| Affiliated Hospital of West Anhui Health Vocational College, Lu 'an, Anhui Province, 237000 |
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Abstract To analyze the clinicopathological feature of the asymptomatic endometrial thickening of postmenopausal women, and to explore the high risk factors of endometrial cancer and precancerous lesions of the postmenopausal women with endometrial thickening. Methods: The clinical data of the postmenopausal women with endometrial thickening from October 2017 to September 2020 were selected as the research subjects. The women were divided asymptomatic women in group A and symptomatic women in group B. The women in group A were also divided into group C (women with endometrium ≥10mm) and group D (women with endometrium <10mm) according to their different endometrium thickness. The clinical data and pathological types of the patients were compared among these groups. The independent influencing factors of endometrial carcinoma and precancerous lesions of the women were analyzed. Results: The endometrial thickness, and the proportions of age ≥60 years old, body mass index (BMI) ≥25kg/m2, hypertension, and tamoxifen used of the women in group A were significantly lower than those of the women in group B (all P＜0.05). There were no significant differences in the proportions of birth ≥2 times, menopausal duration ≥5 years, and diabetes of the women between group A and group B (P＞0.05). The proportions of atypical hyperplasia and endometrial cancer of the women in group A were significantly lower than those of the women in group B (P＜0.05), and there were no significant differences in the proportions of atrophic endometrium, proliferative endometrium, uterine fibroids, and endometrial polyps of the women between group A and group B (P＞0.05). The proportions of BMI≥25kg/m2, hypertension, and tamoxifen used of the women in group D were significantly lower than those of the women in group C (P＜0.05). There were no significant differences in the proportions of age ≥60 years old, childbirth ≥2 times, duration of menopause ≥5 years, and diabetes mellitus, atrophic endometrium, proliferative endometrium, uterine fibroids, endometrial polyps, and atypical hyperplasia of the women between group C and group D (P＞0.05). BMI≥25kg/m2, endometrium ≥10mm, and hypertension of the women were the independent risk factors of their endometrial cancer and precancerous lesions (P＜0.05). Conclusion: The clinicopathological data of the asymptomatic postmenopausal women with endometrium thickening are quite different from those postmenopausal women with symptoms. As the risk of endometrial malignancy of the asymptomatic postmenopausal women with endometrium thickening is low, invasive examination should not be performed for all postmenopausal women with endometrial thickening. The comprehensive evaluation should be made based on endometrial thickness and clinical data, and the postmenopausal women with obesity, endometrial thickness ≥10mm, high blood pressure, or other high-risk factors should be actively treated.
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