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| Predictive value of the peripheral blood abnormal glycochain glycoprotein level combined with the positive rate of human papillomavirus and the intercellular adhesion molecule-1 level for the postoperative recurrence of cervical cancer of perimenopausal women and its correlation with the prognosis of the patients |
| 1.Hainan Medical College, Haikou, Hainan Province, 571199；2.The Second Affiliated Hospital of Hainan Medical College；3. The First People's Hospital of Tianmen of Hubei Province |
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Abstract To analyze the predictive value of the peripheral blood abnormal glycochain glycoprotein (GGP) level combined with the positive rate of human papillomavirus (HPV) and the intercellular adhesion molecule-1 (ICAM-1) level for the postoperative recurrence of cervical cancer of perimenopausal women, and to study its correlation with the prognosis of the patients. Methods: A total of 132 perimenopausal women who wanted radical cervical cancer surgery were selected in study group from January 2020 to January 2021. 77 healthy women who had accepted gynecological examination were selected in control group during the same period. The peripheral blood abnormal GGP level, and the positive rate of HPV, and the level of ICAM-1 of the women in the study group before surgery and the women in the control group were detected. The women in the study group were further divided in group A (women with the postoperative recurrence of cervical cancer) and group B (women without the postoperative recurrence of cervical cancer) after 1 year of follow up. The clinicopathological data and the levels of GGP and ICAM-1, and the positive rate of HPV of the women were compared between group A and group B. The efficacy of the levels of TAP and ICAM-1, and the positive rate of HPV for predicting the postoperative recurrence of cervical cancer of the women was analyzed. Spearman correlation coefficient was used to analyze the correlation between the positive rate of HPV and the GGP and ICAM-1 levels of the women and their postoperative recurrence of cervical cancer. Results: The serum TAP and ICAM-1 levels and the positive rate of high-risk HPV of the women in the study group were significantly higher than those of the women in the control group before surgery (all P＜0.001). The serum TAP and ICAM-1 levels and the positive rate of high-risk HPV of the women with recurrence in 12 months after surgery in the study group were significantly higher than those of the women with recurrence in 3 months after surgery. The serum TAP and ICAM-1 levels, and the positive rate of high-risk HPV of the women in group B in 12 months after surgery were significantly lower than those of the women before surgery and in 3 months after surgery. The serum TAP and ICAM-1 levels, and the positive rate of high-risk HPV of the women in group A were significantly higher than those of the women in group B (all P＜0.001). The area under the curve (AUC) of the combination of the serum TAP and ICAM-1 levels, and the positive rate of high-risk HPV of the women for predicting the postoperative recurrence of cervical cancer of the women was 0.979, which was significantly higher than that of the TAP level, the ICAM-1 level, or the positive rate of high-risk HPV alone. Spearman correlation coefficient analysis showed that serum TAP and ICAM-1 levels and the positive rate of high-risk HPV were significantly positively correlated with their postoperative prognosis of the women in the study group after surgery (all P＜0.05). Conclusion: The detections of the serum TAP and ICAM-1 levels, and the positive rate of high-risk HPV of the perimenopausal women after radical resection surgery of cervical cancer has a certain effect for predicting their postoperative recurrence of cervical cancer. The serum TAP and ICAM-1 levels, and the positive rate of high-risk HPV of the women are correlated with their postoperative prognosis, which suggest that the detections of the serum TAP and ICAM-1 levels, and the positive rate of high-risk HPV of the women after surgery should be strengthened in clinic, so as to improve their efficacy of surgical treatment and survival.
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