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| Influence of prednisone and aspirin assisted by Gushen antai pill for treating women with unexplained recurrent miscarriage on their peripheral blood immune cells, and their levels of fibrin degradation products and D-dimer |
| Nanyang Central Hospital, Henan Province, 473000 |
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Abstract To investigate the effect of prednisone and aspirin assisted by Gushen antai pill for treating women with unexplained recurrent miscarriage (URM), and to study its influence on their peripheral blood immune cells, and their levels of fibrin degradation products (FDP) and D-dimer (D-D). Methods: A total of 92 women with URM were selected as the research objects and were divided into two groups (46 cases in each group) according to the random number table method from November 2019 to November 2020. After the intrauterine pregnancies of the women in the two groups were confirmed, the women in control group were treated with prednisone and aspirin, and the women in the study group were treated with prednisone and aspirin assisted by Gushen antai pill. And the treatments of the women in the two groups were continued until their 12 gestational weeks. The endometrial receptivity indexes, such as the subendometrial artery resistance index (RI), pulsatile index (PI), and the endometrial thickness, the levels of the peripheral blood immune cells (T cells and NK cells), FDP, and D-D of the women before and after treatment were compared between the two groups. The curative effect, the adverse reactions rate, and the pregnancy outcomes of the women in the two groups within 1 year of follow up after treatment were analyzed. Results: After treatment, the values of RI and PI of the subendometrial artery of the women in the two groups had decreased significantly, and which of the women in the study group (0.63±0.05 and 1.80±0.22) were significantly lower than those (0.75±0.07 and 2.07±0.27) of the women in the control group. The endometrial thickness of the women in the two groups had increased significantly, and which of the women in the study group (7.72±1.17mm) was significantly higher than that (7.15±1.06mm) of the women in the control group. The T cell level of the women in the two groups had increased significantly, the levels of NK cell, FDP and D-D of the women in the two groups had decreased significantly, and the improvement degrees of which of the women in the study group were significantly more than those of the women in the control group (all P＜0.05). The total effective rate (91.3%) of the women in the study group was significantly higher than that (73.9%) of the women in the control group (P＜0.05), and there was no significant difference in the adverse reactions rate (8.7% vs. 13.0%) of the women between the two groups (P＞0.05). After 1 year of follow-up, the live birth rate (91.1%) of the women in the study group was significantly higher than that (75.0%) of the women in the control group (P＜0.05). Conclusion: The application of prednisone and aspirin assisted by Gushen antai pills for treating the women with URM can increase their endometrial receptivity, regulate their levels of immune cells, FDP, and D-D, and improve the internal environment of their body, thereby which can improve their pregnancy outcomes safely.
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