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| Clinical efficacy of different doses of folic acid for treating obese patients with polycystic ovary syndrome and its influence on their levels of inflammatory factors |
| Jiaozhou Central Hospital, Qingdao, Shandong Province, 266300 |
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Abstract To analyze the clinical efficacy of different doses of folic acid for treating obese patients with polycystic ovary syndrome (PCOS), and to study its influence on their levels of inflammatory factors. Methods: 150 obese patients with PCOS were selected and divided into group A (75 patients were given 1mg/d folic acid) and group B (patients were given 5mg/d folic acid) according to the different dose of folic acid used from December 2019 to December 2020. The levels of inflammatory factors and glucose and lipid metabolism indicators, and the rate of adverse reactions of the patients before and after treatment were compared between the two groups. Results: After treatment, the levels of hypersensitive C-reactive protein, interleukin-18, and tumor necrosis factor-α of the patients in the two groups had decreased significantly (P＜0.05), but which of the patients had no significant difference between the two groups (P＞0.05). The values of insulin resistance indexes of the patients after treatment had decreased significantly, and the fasting insulin level of the patients in group B (9.15±4.11 mIU/L) was significantly lower than that (12.37±4.79 mIU/L) of the patients in group A. The levels of total cholesterol and low density lipoprotein of the patients in the two groups after treatment had decreased significantly, and which (3.12±1.05 mmol/L and 2.23±0.71 mmol/L) of the patients in group B were significantly lower than those (4.23±1.05 mmol/L and 2.96±0.90 mmol/L) of the patients in group A (P＜0.05). There was no any patient with obvious adverse reactions in both groups after treatment. Conclusion: 5mg/d folic acid for treating the obese patients with PCOS can reduce their subclinical inflammation and insulin resistance, and which has better therapeutic effect without increase of the side effects.
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