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| Relationship between the expression levels of serum galactose lectin 9 (GAL9), brain-derived neurotrophic factor (BDNF), and plasminogen activator inhibitor type 1 (PAI-1) of patients and their endometriosis r AFS stage and the predictive value of the levels of serum GAL 9, BDNF, and PAI-1 for postoperative recurrence of endometriosis |
| Guangzhou Panyu Central Hospital, Guangdong Province, 511400 |
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Abstract To study the relationship between the expression levels of galactose lectin 9 (GAL9), brain-derived neurotrophic factor (BDNF), plasminogen activator inhibitor type 1 (PAI-1) of patients and their r AFS stage of endometriosis (Ems), and to study the predictive value of the levels of serum GAL 9, BDNF, and PAI-1 of the patients for their postoperative recurrence of Ems. Methods: In this prospective study, 104 patients with Ems who were selected in research group, and 104 normal pregnant women who underwent physical examination were selected in control group from February 2018 to December 2018. The levels of Gal 9, BDNF, and PAI-1 of the patients were compared between the two groups, and which of the patients in the research group were compared among the patients with different Ems stage and among the patients with different recurrence of Ems. And the predictive efficacy of the levels of Gal 9, BDNF, and PAI-1 for postoperative recurrence of Ems was analyzed. Results: The levels of Gal 9 (637.51±52.34 ng/L), BDNF (227.58±42.19 mg/L), and PAI-1 (1357.38±122.92 pg/ml) of the patients in the research group were significantly higher than those (245.83±52.32 ng /L, 157.86±41.82 mg/L, and 818.26±102.55 pg/ml) of the patients in the control group, and which of the patients with Ems stage Ⅲ-Ⅳ in the research group were significantly higher than those of the patients with Ems stageⅠ-Ⅱ, and which of the patients with postoperative recurrence of Ems were significantly higher than those of the patients without postoperative recurrence of Ems (all P<0.05). The area under curve of the combined levels of Gal 9, BDNF, and PAI-1 for diagnosing postoperative Ems recurrence was 0.892, which was significantly higher than that of Gal 9 level, BDNF level, or PAI-1m level alone. The critical values of Gal 9 level, BDNF level, and PAI-1m level for predicting postoperative Ems recurrence were 811.23 ng/L, 1801.63 pg/ml, and 269.65 mg/L, respectively. Conclusion: The expression levels of serum Gal-9, BDNF, and PAI-1 of the patients with Ems increase abnormally, and which will increase with the rAFS stage of Ems rising and with the postoperative Ems recurrence. The combined levels of Gal 9, BDNF, and PAI-1 of the patients for diagnosing their postoperative Ems recurrence has clinical value.
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