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| Correlation between the changes of plasma antithrombin III, activity of protein C and protein S of women and their recurrent spontaneous abortion |
| Guangdong Maternal and Child Health Care Hospital, Guangzhou, Guangdong Province, 511442 |
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Abstract To explore the changes of plasma antithrombin III (AT-III), activity protein C (PC) and protein S (PS) of women with recurrent spontaneous abortion (RSA), and to study the value of activity changes of plasma AT-III, PC, and PS for predicting RSA of the women. Methods:100 women with RSA (miscarriage >2 times) were selected in group A, 100 women with the first miscarriage were selected in group B, and 100 women with normal pregnancy and without history of miscarriage were selected in group C from January 2019 to March 2020. The levels of plasma AT-III, PC, and PS of the women were detected and were compared among the three groups. Results: The levels of plasma AT-III, PC, and PS activity of the women in group A, in group B, and in group C had increased gradually (P<0.05). The receiver operator characteristic (ROC) curve analysis showed that the optimal critical value of the plasma AT-III level for predicting RSA was 92.1%, the area under curve (AUC) of ROC of which was 0.779, the sensitivity of which was 83.7%, and the specificity of which was 64.9%. The optimal critical value of the plasma PC level for predicting RSA was 89.47%, AUC of ROC of which was 0.704, the sensitivity of which was 72.3%, and the specificity of which was 77.5%. The optimal critical value of the plasma PS level for predicting RSA was 84.3%, AUC of ROC of which was 0.752, the sensitivity of which was 79.2%, and the specificity of which was 70.3%. Conclusion: The activities of plasma AT-III, PC, PS of the women with RSA decrease abnormally, which suggests that there is a tendency to hypercoagulability of blood of these women. The detections of the plasma AT-III, PC and PS activity have clinical value for predicting RSA of the women.
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