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Abstract To explore the predictive value of urinary immunoglobulin (IgG), microalbumin（mALB），β2-microglobulin (β2-MG), and urinary albumin/creatinine ratio (ACR) of pregnant women with gestational diabetes mellitus (GDM) for their early impairment of renal function. Methods: A total of 90 pregnant women with GDM were selected in group A, 90 healthy pregnant women were selected in group B, and 90 healthy women without pregnancy were selected in group C from January 2019 to March 2020. The women in group A were further divided into group A1 (women with normal renal function) and group A2 (women with impairment of renal function) based on the renal biochemistry indexes of the women. The levels of IgG, mALB, β2-MG, and ACR of the women were detected and compared among these groups. The predictive value of IgG, mALB, β2-MG, and ACR of the women with GDM for their early impairment of renal function was analyzed by receiver operating characteristic curve (ROC). Results: The levels of urinary IgG, mALB, β 2-Mg, and ACR of the women in group A, group B, and group C had decreased gradually, and which of the women in group A2 were significantly higher than those of the women in group A1 (all P<0.05). ROC curve analysis showed that the area under curve (AUC) of urinary IgG, mALB, β2-MG, and ACR of the women with GDM for predicting their early renal function impairment were 0.786, 0.832, 0.841, and 0.853, respectively, the sensitivities of which were 74.1%, 75.0%, 75.4%, and 80.4%, respectively, and the specificity of which w was 69.4%, 73.5%, 75.5% and 85.3%, respectively. The AUC, the sensitivity, and the specificity of the combination the levels of urinary IgG, mALB, β 2-Mg, and ACR of the women with GDM for predicting their early renal function impairment were 0.946, 96.4%, and 97.4%, respectively. Conclusion: The levels of urinary IgG, mALB, β2-MG, and ACR of the pregnant women with GDM increase abnormally, which are all helpful to predict the early renal function impairment of the women. The combination the levels of urinary IgG, mALB, β 2-Mg, and ACR of the pregnant women with GDM has higher diagnostic efficacy for early renal function impairment.
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