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| Effect of low-dose aspirin combined with vitamin E for treating women with high-risk of preeclampsia |
| 1. Shannxi Provincial People’s Hospital，Xi'an, Shannxi Province, 710000；2. Xijing Hospital of Xi'an；3. The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an |
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Abstract To explore the effects of low-dose aspirin combined with vitamin E for treating pregnant women with high-risk of preeclampsia on their oxidative stress, inflammatory factors, and maternal and infant outcomes. Methods: A total of 140 pregnant women with high-risk of preeclampsia during 16 to 22 gestational weeks were selected as the research subjects and were randomly divided into two groups (70 cases in each group) according to the method of random number table from January 2019 to January 2020. The women in both groups were given 75mg/d aspirin until 36 gestational weeks (orally administrated before bedtime every day). And the women in the research group were additionally given 100mg/d vitamin E soft capsules until delivery. The levels of serum oxidative stress and inflammatory factors before treatment and before delivery, and the maternal and infant outcomes, of the women in the two groups were observed. Results: The levels of serum malondialdehyde (MDA), tumor necrosis factor -α(TNF-α), interleukin-6 (IL-6), and hypersensitive C-reactive protein (HS-CRP) of the women in the two groups had decreased significantly after treatment, and the levels of superoxide dismutase orgotein (SOD), catalase (CAT), and total antioxidant capacity (T-AOC) of the women in the two groups had increased significantly after treatment, and the rangeability of which of the women in the research group were significantly higher than those of the women in the control group (all P<0.05). The incidences of the premature rupture of membranes (5.7%) and the fetal growth restriction (10.0%) of the women in the research group were significantly lower than those (18.6% and 22.9%) of the women in the control group (all P<0.05). There were no significant differences in the incidences of perinatal adverse events, such as postpartum hemorrhage and hemolysis, of the women between the two groups. The values of neonatal birth weight, gestational age, neonatal head circumference, and 1min Apgar score in the research group were significantly higher than those in the control group. The incidences of neonatal asphyxia (10.0%), premature infants (14.3%), and low birth weight infants (12.9%) in the research group were significantly lower than those (24.3%, 30.0%, and 27.1%) in the control group (all P<0.05). There was no significant difference in the incidence of neonatal fetal distress between the two groups (P>0.05). Conclusion: Low-dose aspirin combined with vitamin E for treating pregnant women with high-risk of preeclampsia can significantly inhibit their oxidative stress and inflammatory response, effectively control the condition of preeclampsia, and promote their fetal healthy development, thereby can improve the maternal and infant outcomes.
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