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| Application of the precision medicine of aspirin for treating patients with immune recurrent spontaneous abortion |
| The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian Province, 361021 |
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Abstract To exploration of the gene detection for the instructional aspirin precision medicine for patients with immune recurrent spontaneous abortion. Methods: 50 patients with recurrent spontaneous abortion who had treated in hospital between June 2022 and December 2023 were collected in this study. The genetic testing based on blood samples of these patients were conducted before their aspirin administration, and the medication regimen of aspirin was adjusted according to the genetic testing results. Results: Genetic testing was performed on 50 patients with recurrent spontaneous abortion. Three genotypes GG, GA, and AA of the aspirin resistance genes CYP2C19 and CHIA were detected, and three genotypes AC, CC, and AA of gene LTC4S were detected. Two genotypes CC and CT of drug efficacy gene GP1BA were detected. All the genotypes detected of gene PTGS1 were AA. Based on the gene test results, the subsequent guidance of aspirin administration was provided to the patients. Among 50 patients with aspirin used, 21 cases had changed their treatment regimens, and 3 cases had continual their treatment regimens but required close monitoring of their drug adverse reactions. Conclusion: Aspirin pharmacogenomic testing for the patients with recurrent miscarriage can precisely guide their clinical drug used.
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