To compare the clinical effects and radiotoxic side effects of two doses of digital subtraction angiography (DSA) in uterine artery embolization for the interventional treatment of ectopic pregnancy. Methods: A total of 100 patients with ectopic pregnancy who accepted interventional treatment of uterine artery embolization were selected and were divided into two groups (50 cases in each group) by random numbers table from April 2017 to December 2019. The patients in group A were given standard dose DSA mode and the patients in group B were given low dose DSA mode. The therapeutic effect and radiation toxicity of the patients were compared between the two groups. Results: There were no significant differences in the operative time, the intraoperative blood loss, the postoperative blood loss, and the hospital stay time of the patients between the two groups. There was no significant difference in the radiation exposure time (6.97±1.92 min vs. 7.42±1.98 min) of the patients between the two groups (P>0.05). The radiation dose of the patients in group A (22.19± 6.88mGy) was significantly higher than that (10.29±3.13mGy) of the patients in group B (P<0.05). The rates of excellent and good quality of DSA image of the patients in group A were 84.0% and 16.0%, which had no significant different from those (82.0% and 18.0%) of the patients in group B (P>0.05). There were no significant differences in the postoperative mass diameter, the recovery time of serum β-HCG level, and the menstrual recovery time of the patients between the two groups (P>0.05). There was no significant difference in the postoperative blood loss (102.31±22.42 ml vs. 99.82±20.37ml) of the patients between the two groups (P>0.05). There were no significant differences in the incidences of liver dysfunction, gastrointestinal reaction, oral ulcer, contrast agent extravasation, contrast agent allergy, and other toxic reactions of the patients between the two groups (P>0.05). Conclusion: In the interventional treatment of uterine artery embolization for ectopic pregnancy, the image quality, surgical indicators, recovery effect, and toxic and side effects, and other index of the low-dose DSA mode are equivalent to those of the standard dose DSA, and which can significantly reduce the radiation dose and reduce DSA damage to the patient's body.