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| Effects of Cangfu daotan decoction combined with clomiphene citrate for treating patients with infertility caused by polycystic ovary syndrome on their ovarian function, endometrial blood flow parameters, and pregnancy |
| 1.Binhai New District Hospital of Traditional Chinese Medicine, Tianjin, 300451；2. Tianjin Medical University General Hospital |
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Abstract To investigate the effects of Cangfu daotan decoction combined with clomiphene citrate for treating patients with infertility caused by polycystic ovary syndrome (PCOS) on their ovarian function, endometrial blood flow parameters, and pregnancy situation. Methods: A total of 108 patients with infertility caused by PCOS were selected as the research objects and were divided into three groups (36 cases in each group) by random number table method from April 2018 to February 2020. The patients in group A were given clomiphene citrate, the patients in group B were given Cangfu daotan decoction, and the patients in group C were given Cangfu daotan decoction combined with clomiphene citrate. The efficacy of the patients in the three groups was judged after 3 menstrual cycles of treatment. The ovarian function indexes, endometrial blood flow parameters, and the pregnancy rate within 1 year after treatment of the patients in the three groups were counted. Results: The total effective rate (91.7%) of the patients in group C was significantly higher than that (63.9%) of the patients in group A, and that (69.4%) of the patients in group B. The pregnancy rate (66.7%) of the patients in group C was significantly higher than that (38.9%) of the patients in group A, and that (41.7%) of the patients in group B (all P<0.05). After treatment, the ovarian volume and the number of ovarian basal antral follicles of the patients in the three groups had decreased significantly, and the endometrial thickness of the patients in the three groups had increased significantly, and which of the patients in group C were significantly better than those of the patients in group A and group B (all P<0.05). After treatment, the pulbeat index and resistance index of endometrial blood flow of the patients in the three groups had decreased significantly, and which of the patients in group C were significantly better than those in group A and group B (all P<0.05). Conclusion: Cangfu daotan decoction combined with clomiphene citrate for treating the patients with infertility caused by PCOS has better effect, which can significantly improve the ovarian function and endometrial blood flow parameters of the patients, and can effectively increase their pregnancy rate.
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