To investigate the clinical effect of indomethacin suppository combined with oxycodone and acetaminophen tablet for postoperative analgesia of patients who had undergone uterine artery embolization (UAE). Methods: 80 patients with UAE who received treatment in the hospital were selected and were divided into two groups according to the random number grouping criteria (40 cases in each group) from January 2019 to January 2024. The patients in the control group were treated with oxycodone and acetaminophen tablet for the postoperative analgesia, while the patients in the study group were treated with indomethacin suppository combined with oxycodone and acetaminophen tablet for the postoperative analgesia. The postoperative pain score evaluated by visual analogue scale (VAS), the values of vital signs, such as diastolic blood pressure (DBP), pulse rate (PR) and systolic blood pressure (SBP), the comfort degree evaluated by Bruggrmann comfort score (BCS), the adverse reactions rate and the postoperative recovery status of the patients were compared between the two groups. Results: The VAS score of the patients in the two group at postoperative 3h, 6h, 12h, 24h, or 48h was significantly lower than that of the patients at postoperative immediately, and which of the patients in the study group at different time point was significantly lower than that of the patients in the control group. The BCS score of the patients in the two group at postoperative 3h, 6h, 12h, 24h, or 48h was significantly higher than that of the patients at postoperative immediately, and which of the patients in the study group at different time point was significantly higher than that of the patients in the control group. The values of DBP, PR and SBP of the patients in the two group at postoperative 6h or 12h were significantly lower than those of the patients at postoperative immediately, and which of the patients in the study group at postoperative 6h or 12h were significantly lower than those of the patients in the control group (all P<0.05). There was no significant difference in the adverse drug reaction rate (5.0% vs. 12.5%) of the patients between the two groups (P>0.05). The first time getting out of bed (19.52±3.25 h) and the postoperative hospital stay (10.65±3.93 d) of the patients in the study group were significantly shorter than those (25.26±3.46 h and 14.64±3.85 d) of the patients in the control group (all P<0.05). Conclusion: Indomethacin suppository combined with oxycodone and acetaminophen tablet used for the postoperative analgesia of the patients after UAE has significant effect, with higher comfort degree and better postoperative recovery of the patients.