|
|
|
| Value of ultrasound combined with serum creatine kinase and CXCL10 levels for diagnosing hydatidiform mole and for predicting the malignant transformation of hydatidiform mole |
| Huai'an Medical District, General Hospital of Eastern Theater Command, Huai'an, Jiangsu Province, 223001 |
|
|
|
|
Abstract To study the diagnostic efficacy of ultrasound combined with serum creatine kinase (CK) and CXCL10 for hydatidiform mole, and to explore their predictive value for malignant transformation of hydatidiform mole. Methods: 88 patients with gestational trophoblastic disease were selected prospectively in study group from February 2018 to July 2021, which included 40 patients with malignant transformation of gestational trophoblastic disease in malignant group and 48 patients without malignant transformation in non-malignant group. In addition, 88 volunteers who underwent physical examination during the same period were selected in control group. The ultrasonic indexes of all these patients were examined, and their levels of serum CK and CXCL10 were detected, and the efficiencies of which for diagnosing hydatidiform mole and the malignant transformation of gestational trophoblastic disease were analyzed. Results: The levels of serum CK (109.76±1.17μg/ml) and CXCL10 (76.55±1.77 ng/ml) of the patients in the study group were significantly higher than those (29.98±1.01μg/ml and 40.26±1.74 ng/ml) of the patients in the control group, and which of the patients in malignant group (171.89μg/ml±8.24, and 92.59±5.97 ng/ml) were significantly higher than those (57.99±9.19μg/ml and 63.18±5.00 ng/ml) of the patients in the non-malignant group. In the case group the ultrasonic RI,PI and PSV were lower than those in the control group, the EDV was higher than those in the control group, and the RI, PI and PSV in the malignant group were lower than those in the non-malignant group, and the EDV was higher than those in the non-malignant group (all P<0.05). Receiver operating characteristic curve analysis showed that the areas under the curve and the specificity of ultrasound combined with serum CK and CXCL10 levels for diagnosing hydatidiform mole and the malignant transformation were 0.909 and 0.998, and 56.3% and 41.9%, which were all significantly higher than those diagnosed by ultrasound or serum CK and CXCL10 levels alone. Conclusion: Ultrasound combined with serum creatine kinase and CXCL10 levels for diagnosing hydatidiform mole and its malignant transformation has better efficacy, which can be as references in clinic.
|
|
|
|
|
|
|
|
|
