|
|
|
| Correlation between the expression of acetaldehyde dehydrogenase 1 and sex determining region Ybox protein 2 of patients with ovarian serous tumors and their prognosis |
| 1.Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi Province, 712046; 2.The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang; 3. Northwest Women's and Children's Hospital |
|
|
|
|
Abstract To investigate the expression of acetaldehyde dehydrogenase 1 (ALDH1) and sex determining region Y-box protein 2 (SOX2) in the ovarian serous tumor tissues of the patients, and to study the correlation between the ALDH1 and SOX2 levels of the patients and their prognosis. Methods: From June 2017 to June 2018, 79 patients with ovarian serous tumors who would surgically treat were selected as the research objects, and the general information and clinicopathological parameters of the patients were collected. 79 pathological tissue specimens of these patients were collected during the operation, and these patients were divided into group A (54 cases with malignant ovarian serous tumors), group B (15 cases with ovarian borderline serous tumor), and group C (10 cases with benign ovarian serous cystadenoma) according to their pathological results. The expressions of ALDH1 and SOX2 proteins in the tissues were detected by immunohistochemical staining. These patients were followed up for 3 years. The correlation between ALDH1 and SOX2 expression levels of the patients and their clinical pathological parameters and the factors affecting the prognosis of the patients were analyzed. Pearson method was used to analyze the correlation between the expression level of ALDH1 in ovarian serous tumor tissue of the patients and their SOX2 level. Kaplan-Meier method was used to analyze the correlation between the different ALDH1 and SOX2 expression levels of the patients and their survival time. Results: The high expression rates of ALDH1 protein in serous ovarian serous tumors tissues of the patients in group A, group B, and group C were 66.7%, 46.8%, and 20.0%, respectively, and the high expression rates of SOX2 protein in serous ovarian serous tumors tissues of the patients in group A, group B, and group C were 83.3%, 26.7%, and 20.0%, respectively, which were all decreased gradually (P<0.05). There was a positive correlation between the ALDH1 expression and the SOX2 expression in pathological tissues (P<0.05). Univariate analysis showed that the FIGO stage, the lymph node metastasis, the pelvic invasion, the greater omentum metastasis, and ki-67, ALDH1, and SOX2 protein expressions of the patients were correlated with their prognosis (P<0.05). Kaplan-Meiermeie analysis showed that the 3-year cumulative survival rate of the patients with high ALDH1 and SOX2 protein expressions was significantly lower than that of the patients with low ALDH1 and SOX2 protein expressions (P=0.000). Conclusion: ALDH1 and SOX2 proteins are highly expressed in the ovarian serous tumors tissues, and their expressions are obviously positively correlated with their severity of disease. The expression levels of ALDH1 and SOX2 proteins of the patient are closely related to their disease development, and which have certain reference value for predicting the prognosis of patients.
|
|
|
|
|
|
|
|
|
