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| Value of serum IgG anti-A (B）antibody titer of pregnant women with blood type O for predicting the hemolytic disease of newborn |
| Sanya Central Hospital, Sanya, Hainan Province, 572000 |
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Abstract To study the value of serum immunoglobulin G (IgG) anti-A (B) antibody titer of pregnant women with blood type O for predicting the hemolytic disease of newborn (HDN). Methods：385 pregnant women with blood type O were selected as the study subjects from December 2016 to December 2020. Antiglobulin detection was used to detect serum IgG anti-A（B）antibody titer of these women，and serological test for HDN was performed in the newborns of these women. Receiver operating characteristic （ROC）curve was used to analyze the value of serum IgG anti-A（B）antibody titer of the women for predicting their HDN. Results：In the 385 pregnant women with blood type O, the proportions of their serum IgG anti-A (B) antibody titers ≤1:32, 1:64, 1:128, 1:256, ≥ 1:5152 were 17.7%, 27.0%, 21.8%, 18.7%, 14.8%, respectively. The proportion of IgG anti-A (B) antibody titer ≥1:512 of the pregnant women with blood type O-A was significantly higher than that of the pregnant women with blood type O-B and O-AB (P<0.05), and there was no significant difference in the positive rate of HDN among the women with blood type O-A, O-B, and O-AB (P>0.05). The incidence of HDN in the pregnant women with serum IgG anti-A (B) antibody titer ≥ 1:512 had no significant different from that of the pregnant women with serum IgG anti-A (B) antibody titer 1:256, but which was significantly higher than that of the pregnant women with serum IgG anti-A (B) antibody titer ≤1:32, 1:64, or 1:128. The incidence of HDN in the pregnant women with serum IgG anti-A (B) antibody titer ≤1:32, 1:64, 1:128 had increased gradually (P<0.05). ROC curve analysis showed that the sensitivity, the specificity, and the area under curve of the serum IgG anti-A (B) antibody titer for predicting the HDN were 96.0%, 68.0%, and 0.848, respectively. Conclusion：The serum IgG anti-A（B）antibody titer of the pregnant women with blood type O for predicting their HDN occurrence has higher value，which maybe as a reference index for early intervention in clinic.
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