|
|
|
| Correlation between serum neutrophil gelatinase associated lipid carrier protein expression of the pregnant women with gestational diabetes mellitus and their disease progression |
| 1. Haikou Maternal and Child Health Hospital, Haikou, Hainan Province, 571100；2. Hainan Women and Children Medical Center |
|
|
|
|
Abstract To explore the correlation between the expression of serum neutrophil gelatinase associated lipid carrier protein (NGALP) of pregnant women with gestational diabetes mellitus (GDM) and the progression of their GDM. Methods: Retrospective analysis of the clinical data of 136 pregnant women from January 2018 to December 2019 was conducted, which included 68 pregnant women with GDM in observation group and 68 healthy pregnant women in control group. The levels of serum NGAL, fasting blood glucose (FBG), and fasting insulin (FINS) of the women during the first, the second, and the third trimester of pregnancy were measured. The value of homeostasis model assessment of insulin resistance (HOMA-IR) of the women was calculated. Logistic regression was used to analyze the correlation between NGAL level of the women and the progression of their GDM. Results: The levels of serum NGAL (20.74± 4.11 ng/ml, 50.02± 4.95 ng/ml, and 51.04± 5.02 ng/ml) during the first, second and third trimester of pregnancy of the women in the observation group were significant higher than those (9.91± 2.27 ng/ml, 14.71±3.54 Ng/ml, and 14.98±3.61 ng/ml) of the women in the control group. The level of FBG or FINS, or HOMA-IR value during the first, the second, and the third trimester of pregnancy of the women in the observation group was significant higher than that of the women in the control group. The levels of serum NGAL, FBG, and FINS, and the HOMA-IR value of the women in the observation group during the second and the third trimester of pregnancy were significant higher than those of the women during the first trimester of pregnancy. The levels of serum NGAL, FBG, and FINS, and the HOMAIR value of the women in the control group during the second and the third trimester of pregnancy were significant higher than those of the women during the first trimester of pregnancy (all P<0.05). There was no significant difference in level of the serum NGAL of the women during the second trimester of pregnancy between the two groups (P>0.05). Regression analysis showed that the FBG and FINS levels, and the HOMA-IR value of the women were the independent influencing factors of their increased serum NGAL level (P<0.01). Conclusion：The high expression of serum NGAL of the pregnant women is related to the progression of their GDM, so serum NGAL level can be used as one of the clinical reference index for diagnosing GDM early and evaluating the progression and prognosis of GDM.
|
|
|
|
|
|
|
|
|
