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| Correlation of the levels of serum immunoglobulins and inflammatory factors of pregnant women with gestational diabetes mellitus during the third trimester of pregnancy and their puerperal infection |
| The Second People's Hospital of Nanyang, Henan Province, 473000 |
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Abstract To analyze the correlation of the levels of the serum immunoglobulins, such as IgG，IgM, and IgA, and the inflammatory factors of pregnant women with gestational diabetes mellitus (GDM) during the third trimester of pregnancy and their puerperal infection. Methods: 106 pregnant women with GDM during the third trimester were enrolled in this study and were divided into group A (22 women with puerperal infection) and group B (84 women without puerperal infection) according to the presence or absence of puerperal infection between March 2020 and August 2021. Meanwhile，30 healthy pregnant women with normal delivery were selected in group C. The levels of serum IgG，IgM，IgA, tumor necrosis factor -α (TNF-α), interleukin-6 (IL-6), hypersensitive C-reactive protein (HS-CRP) of the women were compared among the three groups, and the correlation between which and the puerperal infection of the women with GDM was analyzed. Results: The serum levels of IgG, IgM, and IgA of the women in group A, group B, and group C had increased in turn, while the levels of TNF-α, hsCRP, and IL-6 of the women in group A, group B, and group C had decreased in turn (all P<0.05). The levels of serum IgG, IgM, and IgA of the pregnant women with GDM during the third trimester of pregnancy were negatively correlated with their puerperal infection occurrence (r=-0.443, -0.455, -0.398, all P<0.05), but the levels of serum TNF-α, hs-CRP, and IL-6 of the pregnant women with GDM during the third trimester of pregnancy were positively correlated with their puerperal infection occurrence (r=0.383, 0.343, 0.440, all P<0.05). Conclusion: The immunity of the pregnant women with GDM during the third trimester of pregnancy decreases，which may lead to their puerperal infection occurrence and decrease the levels of their serum immunoglobulin, such as IgG，IgM，and IgA. The occurrence of puerperal infection of the pregnant women with GDM is negatively correlated with the levels of their serum immunoglobulin, such as IgG，IgM，and IgA during the third trimester of pregnancy，and was positively correlated with the levels of their serum TNF-α，hs-CRP，and IL-6.
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