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| Effect of Guizhi fuling pill combined with gonadotropin-releasing hormone agonist for treating dysmenorrhea of patients after laparoscopic endometriosis treatment |
| 1. Zaozhuang Maternal and Child Health Care Hospital, Shandong Province, 277800; 2.Zaozhuang Vocational College, Zaozhuang, Shandong Province |
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Abstract To investigate the therapeutic effect of Guizhi fuling pill combined with gonadotropin-releasing hormone agonist (GnRH-a) for treating patients with endometriosis (EMT) after laparoscopic surgery. Methods: 104 patients with EMT who would receive laparoscopic surgery were selected as study subjects, and were divided into two groups (52 cases in each group) according to the principle of random number from January 2018 to August 2019. The patients in the control group were treated with GnRH-a after surgery, while the patients in the observation group were treated with Guizhi fuling pill combined with GnRH-a after surgery. The dysmenorrhea score, the degree dysmenorrhea alleviated, and the serological markers levels of the patients were compared between the two groups. Results: The dysmenorrhea scores of the patients in both groups had decreased significantly after treatment, and which of the patients in both groups in the 12th month after treatment were significantly higher those in the 6th month after treatment, and which of the patients in the observation group in the 6th and the 12th month after treatment were significantly lower those of the patients in the control group (P<0.05). There was no significant difference in the total effective rate of dysmenorrhea (90.4% and 76.9%) of the patients between the two groups (P>0.05), and the recurrence rate of dysmenorrhea of the patients in the observation group (3.9%) was significantly lower than that (17.3%) of the patients in the control group (P<0.05). The levels of serum carbohydrate antigen 125 (CA125), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) of the patients in the two groups after 6 and 12 months of treatment had decreased gradually, and the levels of CA125 and TNF-α of the patients in the observation group were significantly lower than those of the patients in the control group. The level of serum IL-6 of the patients in the two groups after 12 months of treatment was significantly lower than that of the patients in the control group (all P<0.05), but there was no significant difference in the IL-6 level of the patients after 6 months of treatment between the two groups (P>0.05). Conclusion: Guizhi fuling pill combined with GnRH-a for treating patients with EMT after laparoscopic surgery can further improve their inflammatory response state, and can reduce their recurrence of dysmenorrhea.
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