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| Meta-analysis of risk factors related to embryo damage |
| 1.Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital Affiliated to Capital Medical University, Beijing, 100026; 2.Aviation General Hospital |
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Abstract To summarize the risk factors of embryo damage by meta-analysis, and to provide evidence for preventing embryo damage. Methods： The literatures were searched in the databases, such as Pubmed，CNKI，Wanfang, and other, till to June 1, 2021 by the key terms of "missed abortion"，"embryonic cessation of development"，and "influencing factors"，"relevant factors", and "risk factors". The case-control studies about the risk factors of embryo damage were collected and were screened according to the determined inclusion and exclusion criteria. Meta-analysis was performed by Revman5.3.0. Results：A total of 30 studies with 34848 cases were enrolled，which included 9850 cases with embryo damage and 24998 without embryo damage. The risk factors of embryo damage were the age of pregnant women ≥35 years old (OR=1.65，95%CI 1.25-2.17)，the chlamydial trachomatis infection (OR=4.15, 95%CI 1.96-8.77), the ureaplasma urealyticum infection (OR=8.15, 95%CI 3.46-19.19)， the smoking (OR=3.02, 95%CI 1.74-5.24)，the alcohol consumption (OR=4.97，95%CI 3.92-6.30)，the previous abortion history (OR=5.59, 95%CI 3.19-9.51)，the unhealthy emotions (OR=3.51, 95%CI 2.34-5.28)，the bad environment(OR=4.36, 95%CI 2.089.17), and the fetal chromosome abnormality (OR=5.83, 95%CI 4.36-7.78), etc. While the folic acid supplementation was a protective factor of embryo damage (OR=0.30, 95%CI 0.21-0.45). Conclusion：There are many risk factors of embryo damage. Early identification and intervention for the pregnant women are conducive to prevent the occurrence of embryo damage, so as to realize the eugenics.
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