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| Correlation between the blood flow index of uterine artery and umbilical artery of pregnant women with fetal growth restriction and their pregnancy associated plasma protein level and their predictive efficacy |
| The First People’s Hospital of Chenzhou, Hunan Province, 423000 |
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Abstract To explore the value of pregnancy-associated plasma protein A (PAPP-A) and the blood flow index of uterine artery and umbilical artery of pregnant women for predicting fetal growth restriction (FGR). Methods: 110 pregnant women with suspect FGR were selected in this study from June 2018 to June 2021. Among them, 60 women with confirmed FGR were in observation group (29 women with severe FGR in group A and 31 women with mild FGR in group B), and the other 50 women were in control group. All these women were examinated by color Doppler ultrasonography. The level of PAPP-A of these women were detected by enzyme-link immunosorbent assay (ELISA). The blood flow parameters of uterine artery and umbilical artery of the women were compared between the two groups. The correlation between the blood flow parameters of uterine artery and umbilical artery of the women and their serum indexes levels, as well as the correlation between the blood flow parameters and the serum indexes levels of the women and their disease severity, and the diagnostic value of the blood flow parameters and the serum indexes levels for diagnosing FGR were analyzed. Results: The values of resistance index (RI), pulsatile index (PI), and peak systolic flow rate/end diastolic flow rate (S/D) of the uterine and umbilical artery blood flow parameters of the women in the observation group were significantly higher than those of the women in the control group, and the values of RI, PI, and S/D of the women with severe FGR were significantly higher than those of the women with mild FGR，but the level of PAPP-A of the women with severe FGR was significantly lower (all P＜0.05). The RI, PI, and S/D values of blood flow parameters of uterine artery and umbilical artery of the women with FGR were positively correlated with their severity of FGR. The level of PAPP-A of the women with FGR was negatively correlated with their severity of FGR. The values of RI, PI, and S/D of the women with FGR were negatively correlated with their PAPP-A level (all P＜0.05). The values of blood flow parameters of uterine artery and umbilical artery of the women had diagnostic efficacy for FGR. The AUC (0.924) of the combination of blood flow parameters of uterine artery and umbilical artery for diagnosing FGR was the highest (P＜0.05), with the sensitivity of 81.3% and the specificity of 80.4%. Conclusion: The values of blood flow parameters of uterine artery and umbilical artery and the level of PAPP-A of the women are correlation with their severity of FGR, so the values of blood flow parameters of uterine artery and umbilical artery of the women have some diagnostic value for FGR.
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