To explore the risk factors and predictor of residual/recurrent lesions after cervical loop electrosurgical excision procedure (LEEP) for treating patients with cervical intraepithelial neoplasia (CIN）2 or CIN 3. Methods: The clinical data of 102 patients who underwent LEEP surgery from January 2015 to December 2019 were selected in this study. The cervical specimens after surgery were examined by TCT, and high-risk human papillomavirus (HR-HPV), colposcopy, and biopsy were also conducted on these patients. These patients were followed up for 1 year after surgery.Results: There was significant difference in the situation of the residual/recurrent of lesions among the patients with different age, the patients with different preoperative HPV load, or the patients with different status of cervical and vaginal external incisal margin (P＜0.05), but there was no significant difference in the situation of the residual/recurrent of lesions among the patients with different pathological grades of cervical lesion before surgery (P＞0.05). Further Logistic multiple regression analysis showed that age >40 years old, preoperative HPV load >1000 pg/ml, and the positive lesion of cervical and vaginal external incisal margin of the patients were all the risk factors of residual/recurrence of lesions after LEEP (P＜0.05). The sensitivity, specificity, and the area under the curve (AUC) of age for predicting residual/recurrence of cervical lesion after LEEP were 75.0%, 81.9%, and 0.765 (0.670-0.843), respectively. The sensitivity, specificity, and the AUC of preoperative HPV loading for predicting residual/recurrence of cervical lesion after LEEP were 87.5%, 70.7%，0.801 (0.7090.874), respectively. The sensitivity, specificity, and the AUC of lesion of cervical and vaginal external incisal margin for predicting residual/recurrence of cervical lesion after LEEP were 75.0%, 85.3%， 0.801 (0.711-0.836), respectively. Conclusion: Advanced age, high preoperative HPV load， and positive lesions of cervical and vaginal external incisal margin are all the risk factors of residual/recurrence of postoperative lesion after LEEP, and which have good predictive values for residual/recurrence of postoperative lesion after LEEP.