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Abstract To explore the changes of urine microalbumin/creatinine ratio (ACR) of pregnant women with preeclampsia (PE), and to analyze their correlation with the severity of preeclampsia and the pregnancy outcomes of these women. Methods: 280 pregnant women with PE were collected in study group, and were divided in group A (n=147 women with high ACR) and group B (n=153 women with low ACR) according to the ACR value between March 2019 and March 2021. Meanwhile, 280 normal pregnant women were selected in control group. The values of mean arterial pressure, 24-hour urine protein content, and ACR value of the women were compared between the study group and the control group and among the women with different severity of PE. The pregnancy outcomes of the women in the study group were followed up. Results: The 24h urinary protein content (0.36±0.09 g), and the values of ACR (73.52±12.73 mg/mmol) and the mean arterial pressure (112.75±8.96 mmHg) of the women in the study group were significantly higher than those (0.07±0.02 g, 20.83±4.65 mg/mmol, and 96.37±5.18 mmHg) of the women in the control group, and which of the women with severe PE were significantly higher than those of the women with mild PE (all P＜0.05). Multiple linear regression analysis showed that the ACR value of the women with PE was significantly positively correlated with their 24h urinary protein content and their mean arterial pressure value (P＜0.05). The incidences of amniotic fluid contamination ≥Ⅲ (21.1%), premature or induced labor (89.1%), fetal death (14.3%), placental abruption (6.8%), and fetal intrauterine distress (17.7%) of the women in group A were significantly higher than those (9.0%, 75.9%, 6.0%, 0.8%, and 9.0%) of the women in group B (P＜0.05). Conclusion: The ACR value of the pregnant women with PE is higher, which is related to their severity of PE and their adverse pregnancy outcomes, so which should be monitored in clinic.
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