Abstract To study the significance of the expression of serum sulfatyltransferase 2A1 (Sult2A1), platelet activating complex -1 (PAC-1), and thyroid peroxidase antibody (TPOAB) of pregnant women with intrahepatic cholestasis of pregnancy (ICP). Methods: 84 pregnant women with ICP were selected in experimental group, and 70 healthy pregnant women who underwent physical examination were selected in control group from January 2019 to December 2019. The changes of serum levels of Sult2A1, PAC-1, and TPOAb of the women and their value for predicting ICP were analyzed. Results: The serum SULT2A1 level (26.68±5.06μmol/L) of the women in the experimental group was significantly lower than that (45.84±7.15μmol/L) of the women in the control group. The levels of PAC-1 (15.63±6.35 %) and TPOAb (19.46±5.35 ng/L) of the women in the experimental group were significantly higher than those (2.52±0.87 % and 9.65±1.25 ng/L) of the women in the control group, and which variation range of the women in the experimental group had increased with the aggravation of ICP (P＜0.05). Receiver operating characteristic curve analysis had showed that the AUC, the sensitivity, the specificity, and the cut-off value of the serum SULT2A1 level for predicting ICP were 0.803, 83.6%, 85.4%, and 34.449μmol/L, respectively. The AUC, the sensitivity, the specificity, and the cut-off value of the serum PAC-1 level for predicting ICP were 0.834, 82.6%, 88.5%, and 4.251%, respectively. The AUC, the sensitivity, the specificity, and the cut-off value of the serum TPOAb level for predicting ICP were 0.830, 84.2%, 86.6%, and 12.257 ng/L, respectively. The sensitivity (93.4%) and the specificity (94.3%) of the combination of levels the serum SULT2A1, PAC-1, and TPOAb for predicting ICP were the highest (P＜0.05). Conclusion: The expressions of serum SULT2A1, PAC-1, and TPOAb of the pregnant women with ICP are abnormal, which have some clinical values for illness monitoring of ICP.
|
