|
|
|
| Effects of low-dose atosiban used before freeze thawing embryo transplantation on the pregnancy outcomes of elderly infertility women with endometriosis |
| 1.The People's Hospital of Rugao, Jiangsu Province, 226500; 2.Zhuji Aima Maternity Hospital |
|
|
|
|
Abstract To explore the effects of low-dose atosiban used before freeze thawing embryo transplantation (F-ET) of elderly infertility women with endometriosis (EMS) on their pregnancy outcomes. Methods: The clinical data of 156 elderly infertility women with EMS who underwent F-ET from April 2019 to November 2020 were analyzed retrospectively, which included 81 women were given atosiban on the F-ET day (in observation group) and 75 women were not given atosiban on the F-ET day (in control group). The pregnancy outcomes and the changes of the positive rates of serum carcinoembryonic antigen 125 (CA125) and antiendometrial antibody (EMAb) of the women were compared between the two groups. The influencing factors of pregnancy outcomes of these women were analyzed. Results: During assisted reproductive therapy, there were no significant differences in the endometrial thickness, the number of transplanted embryos, the number of high-quality embryos, and transfer rate of resuscitated embryos of the women between the two groups (P＞0.05). The serum CA125 level (36.91±17.58 IU/ml) and the EMAb positive rate (6.2%) of the women in the observation group were significantly lower than those (40.58±18.26 IU/ml and 17.3%) of the women in the control group. The embryo implantation rate (33.6%), the clinical pregnancy rate (72.8%), the biochemical pregnancy rate (75.3%), and the live birth rate (60.5%) of the women in the observation group were significantly higher than those (18.2%, 46.7%, 49.3%, and 28.0%) of the women in the control group, and the abortion rate (6.8%) of the women in the observation group was significantly lower than that (22.9%) of the women in the control group (P＜0.05). Univariate and logistic multivariate analysis showed that the situation of atosiban used and the number of high-quality embryos transplanted were beneficial to the pregnancy outcomes of elderly infertility women with EMS (P＜0.05). Conclusion: The application of low-dose atosiban of elderly infertility women with EMS before F-ET can significantly improve their pregnancy outcomes, and increase their clinical pregnancy outcomes.
|
|
|
|
|
|
|
|
|
