|
|
|
| Influence of compound danshen injection combined with labetalol for treating pregnant women with preeclampsia on their oxidative stress reaction factors level in peripheral blood and delivery outcomes |
| 1.Department of Obstetrics and Gynecology, Jinnan Hospital, Tianjin, 300350；2.Tinajin Central Obsterics and Gynecology Hospital |
|
|
|
Abstract To investigate the influence of compound danshen injection combined with labetalol for treating pregnant women with preeclampsia on their oxidative stress reaction factors level in peripheral blood and their delivery outcomes.Methods: 100 pregnant women with preeclampsia were selected and were divided into two groups (50 cases in each group) from June 2019 to December 2020.The women in the control group were treated with magnesium sulfate injection and labetalol hydrochloride, while the women in the observation group were treated with compound danshen injection combined with magnesium sulfate injection and labetalol hydrochloride.The improvement of symptoms, the change of oxidative stress response factors levels in peripheral blood, or the incidence of adverse pregnancy outcomes of the women before and after treatment was compared between the two groups.Results: The values of diastolic blood pressure, systolic blood pressure, 24h urinary protein, and the levels of serum angiotensin Ⅱ(Ang Ⅱ), lipid peroxide (LPO), malondialdehyde (MDA), protein oxidation product (AOPP), C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) of the women in the two groups after treatment had decreased significantly, and which of the women in the observation group were significantly lower than those of the women in the control group (all P＜0.05).The values of neonatal weight (2.77±0.33 kg) and Apgar score (8.03±1.44 points) in the observation group were significantly higher than those (2.14±0.40 kg and 6.78±0.35 points) in the control group (all P＜0.05).There was no significant difference in the total incidence of adverse reactions (12.0% vs.8.0%) of the women between the two groups (P＞0.05).The total incidence of adverse pregnancy outcomes (18.0%) of the women in the observation group was significantly lower than that (38.0%) of the women in the control group (P＜0.05).Conclusion: Compound danshen injection combined with labetalol for treating pregnant women can effectively alleviate their clinical symptoms, reduce the oxidative stress and inflammatory reaction factors levels in peripheral blood, which can help to maintain the growth and development of fetus and reduce the occurrence of adverse pregnancy outcomes.
|
|
|
|
|
|
|
|
|
