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| Effects of modified Atkins diet for intervention of overweight or obese pregnant women with polycystic ovarian syndrome on their glucolipid metabolism, body composition, sex hormone levels, and menstrual cycle |
| Xuzhou Municipal Hospital (The First People's Hospital of Xuzhou), Xuzhou Medical University, Jiangsu Province, 221000 |
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Abstract To explore the effects of the modified Atkins diet (MAD) for intervention of overweight or obese pregnant women with polycystic ovarian syndrome (PCOS) on their glucolipid metabolism, body composition, sex hormone levels, and menstrual cycle.Methods: 80 overweight or obese pregnant women with PCOS who met the inclusion and exclusion criteria at the first or the sixth People's hospital of Xuzhou were recruited as the study subjects from June 1, 2020 to March 31, 2021.These women were divided into experimental group and control group (40 cases in each group) according to the principle of random allocation.The women in the control group were given conventional treatment and lifestyle recommendations for 3 months, and the women in the experimental group were treated with modified Atkins diet (MAD) intervention for 3 months.The baseline assessment was conducted on all these women.The levels of glucose metabolism indexes, lipid metabolism indexes, and sex hormone of the women in the two groups before intervention and 1, 2, 3 months after intervention were compared.The body composition indexes, the menstrual status, and the occurrence of adverse reactions of the women in the two groups before intervention and 3 months after intervention were compared.Results: After 1, 2, 3 months of intervention, the levels of blood glucose, total cholesterol, triglyceride, and low density lipoprotein of the women in the two groups had a decreasing trend, and which of the women in the experimental group were significantly lower than those of the women in the control group.While the level of high density lipoprotein of the women in the two groups had increasing trend, and which of the women in the experimental group was significantly higher than that of the women in the control group (all P＜0.05).Three months after intervention, the body composition indexes, such as body weight, body mass index, body fat percentage, waist circumference, muscle mass, and visceral fat region of the women in both groups had decreased significantly.The values of weight, body mass index, body fat percentage, waist circumference, and visceral fat region of the women in the experimental group were significantly lower than those of the women in the control group, and the value of muscle amount of the women in the experimental group was significantly higher than that of the women in the control group (all P＜0.05).In 1, 2, and 3 months after intervention, the levels of sex hormones of the women in both groups showed a decreasing trend, and which of the women in the experimental group were significantly lower than those of the women in the control group (P＜0.05).The rate of successful nature pregnancy (17.5%) of the women in experimental group was significantly higher than that (2.5%) of the women in control group, and the incidence of adverse reactions (5.0%) of the women in experimental group was significantly lower than that (20.0%) of the women in the control group (all P＜0.05).Conclusion: MAD intervention of the overweight or obese women with PCOS has good effect, which can significantly improve their glucose and lipid metabolism level and body composition indicators, regulate their sex hormone levels, promote the recovery of their menstrual cycle, increase their probability of natural pregnancy, and reduce the probability of adverse reactions.
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