|
|
|
| Association between adiponectin gene rs1501299 (+276G/T) polymorphisms of the pregnant women and their gestational diabetes mellitus: a meta-analysis |
| Jiangsu Health Development Research Center, National Health and Family Planning Commission Contraceptives Adverse Reaction Surveillance Center, Nanjing, Jiangsu Province, 210036 |
|
|
|
|
Abstract To investigate the association between adiponectin gene rs1501299 (+276G/T) polymorphisms of pregnant women and their gestational diabetes mellitus (GDM), and to provide effective data for the prevention and treatment of GDM. Methods: Chinese and English databases such as Wanfang, CNKI, and Pubmed were searched until October 2021. According to the inclusion criteria and exclusion criteria, a total of 11 studies were included in this meta-analysis. State software was used for meta-analysis. Then, heterogeneity detection, sensitivity analysis, and publication bias were performed. Results: As for the five comparison models results of adiponectin gene (+276G/T): T vs. G (OR=0.93, 95%CI:0.83-1.04), TT vs.GG (OR=0.87, 95%CI: 0.67-1.13), TG vs.GG (OR=0.96, 95%CI:0.82-1.13), TT+TG vs.GG (OR=0.94, 95%CI:0.81-1.10), and TT vs. GG+TG (OR=0.87, 95%CI:0.70-1.08), they suggested that adiponectin gene (+276G/T) polymorphism of the women was not associated with the occurrence of GDM. Subgroup analysis based on the race and genotyping methods of the women showed also no statistical significance difference. Conclusion: Adiponectin gene rs1501299 (+276G/T) polymorphism of the pregnant women may not be associated with their GDM.
|
|
|
|
|
|
|
|
|
