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| The balance of the proportion of Treg to Th17 cell in peripheral blood of pregnant women with condyloma and its influence on their pregnancy outcomes |
| 1. Fenghua District Hospital of Traditional Chinese Medicine of Ningbo, Zhejiang Province, 315500; 2. Ningbo Women and Children's Hospital |
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Abstract To investigate the proportion of Treg to Th17 (Treg/Th17) cells in peripheral blood of pregnant women with condyloma (CA), and to study its influence on the pregnancy outcomes of these women. Methods: From October 2018 to October 2020, 112 pregnant women with CA were selected in study group, and 112 normal pregnant women were selected in control group during the same period. Flow cytometry was used to detect the proportion of Treg/Th17 cells in peripheral blood of the women in the two groups. The influence of the imbalance of Treg/Th17 cells in peripheral blood of the women with CA on their pregnancy outcomes was analyzed. Results: The level of Treg (4.56±1.44%) and the proportion of Treg/Th17 cells (4.38±1.48) in peripheral blood of the women in the study group were significantly higher than those (2.60±0.72% and 1.64±0.56) of the women in the control group. The levels of Th17 (1.04±0.35%) in peripheral blood of the women in the study group was significantly lower than that (1.62±0.46%) of the women in the control group (all P＜0.05). ROC curve analysis showed that the Treg and Th17 levels, and the proportion of Th17 and Treg/Th17 cells in peripheral blood of the women had certain values for diagnosing CA (AUC=0.813, 0.814, and 0.946). The rates of cesarean delivery (50.0%) and forceps delivery (12.9%) of the women with CA and the imbalance of Treg/Th17 cells were significantly higher than those (28.6% and 4.8%) of the women without the imbalance of Treg/Th17 cells, but the rate of natural delivery (37.1%) of the women with CA and the imbalance of Treg/Th17 cells was significantly lower than that (66.7%) of the women without the imbalance of Treg/Th17 cells (P＜0.05). There were no significant differences in the rates of full-term birth, preterm birth, abortion, and HPV positive rate of the women, and the rates of perinatal death, neonatal asphyxia, neonatal low body weight, and the incidences of neonatal HPV infection and respiratory papilloma after followed up for 6 months of born between of the women with the imbalance of Treg/Th17 cells and the women without the imbalance of Treg/Th17 cells (all P＞0.05). Conclusion: The women with CA have the imbalance of Treg/Th17 cells in peripheral blood during pregnancy, which may affect the maternal delivery outcomes to a certain extent, but has no significant impact on the adverse pregnancy outcomes of both mothers and infants.
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