|
|
|
| Relationship between gene polymorphism of MTHFR C677T locus of pregnant women and the susceptibility and severity of their preeclampsia and their maternal-infant outcomes |
| Mianyang Central Hospital, Mianyang, Sichuan Province, 621000 |
|
|
|
|
Abstract To analyze the relationship between gene polymorphism of polymorphism of 5,10-methylenetetra hydrofolate reductase (MTHFR) C677T locus of pregnant women and the susceptibility and severity of their preeclampsia and their maternal-infant outcomes. Methods: 104 pregnant women with preeclampsia who were examined and hospitalized for delivery were selected in group A and were divided in 83 women with mild preeclampsia in group A1 and 21 women with severe preeclampsia in group A2 from December 2018 to March 2020. And 88 healthy pregnant women were selected in group B during the same time period. The genotype frequency and allele frequency of MTHFR C677T locus of the women were compared among these groups. The relationship between the gene polymorphism of MTHFR C677T locus of the women and their susceptibility and severity of preeclampsia and their maternal-infant outcomes was analyzed. Results: TT genotype frequency and T allele frequency of MTHFR C677T locus of the women in group A were significantly higher than those of the women in group B, but CC genotype frequency and C allele frequency of MTHFR C677T locus of the women in group A were significantly lower (all P＜0.05), there was no significant difference in CT genotype frequency of MTHFR C677T locus of the women between group A and group B (P＞0.05). MTHFR C677T gene polymorphism of the women was associated with their preeclampsia susceptibility (P＜0.05). The preeclampsia susceptibility of the women with TT genotype increased 3.51 times of that of the women with CT+CC genotype (OR=3.506, 95%CI: 1.501-8.194). There were no significant differences in genotype frequency and gene frequency of MTHFR C677T locus of the women between group A1 and group A2 (P＞0.05). MTHFR C677T gene polymorphism of the women was not associated with the severity of their preeclampsia (P＞0.05). There were no significant differences in the incidences of cesarean section, premature delivery, postpartum hemorrhage, and placental abruption of the women, the values of neonatal body weight and neonatal Apgar score, and the incidences of neonatal asphyxia and intrauterine distress among the women with different genotypes of MTHFR C677T locus (P＞0.05). Conclusion: Gene polymorphism of MTHFR C677T locus of the pregnant women is related to the susceptibility of their preeclampsia, but is not related to the severity of their preeclampsia and their maternal-infant outcomes.
|
|
|
|
|
|
|
|
|
