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| Influence of the rate of blood glucose elevation evaluated by oral glucose tolerance test of pregnant women with gestational diabetes mellitus on their abnormal lipid metabolism and insulin resistance |
| Puyang People's Hospital, Henan Province, 457000 |
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Abstract To analyze the Influence of the rate of blood glucose elevation (Vmean) evaluated by oral glucose tolerance test (OGTT) of pregnant women with gestational diabetes mellitus (GDM) on their abnormal lipid metabolism and insulin resistance. Methods: 216 pregnant women with GDM were selected as subjects from April 2017 to October 2020. The general data of these women were collected, OGTT and insulin release test (IRT) were performed on these women. The levels of serum lipid metabolism index and insulin resistance index of these women were recorded, and Vmean of these women was calculated. According to the mean of Vmean, the women were divided into group A (women with Vmean<0.109 mmol/L·min) and group B(women with Vmean≥0.109 mmol/L·min). Results: Age, the body mass index value, and the HbA1c level of the women in group B were significantly higher than those of the women in group A (P<0.05). The levels of serum TG, TC, and LDL of the women in group B were significantly higher than those of the women in group A (P<0.05), while the HDL level of the women in group B was significantly lower than those of the women in group A (P<0.05). The value of HOMA-IR of the women in group B was significantly higher than those of the women in group A, but the values of HOMA-β andΔI30/ΔG30 of the women in group B were significantly higher than those of the women in group A (P<0.05). The Vmean of the women with GDM was positively correlated with their age, BMI value, HbA1c level, TG level, and HOMA-IR level (r=0.266, 0.307, 0.855, 0.705, 0.289), and was negatively correlated with their values of HOMA-β andΔI30/ΔG30 (r=-0.773, -0.252). Age, BMI value, and HbA1c level of the women with GDM were the independent risk factors of their increase of Vmean (OR=2.305, 95%CI 1.162-3.576; OR=2.168, 95% CI 1.14-4.126; OR=2.983, 95% CI 1.534-5.801). Conclusion: The high Vmean of the pregnant women with GDM can aggravate the degree of their abnormal lipid metabolism and insulin resistance, and advanced age, obesity, and high level of HbA1c are the influencing factors of Vmean of these women.
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