To explore the effects of fluorbillofenester used as preemptive analgesia during painless abortion of women on the dosage of propofol used and the coagulation function of women. Methods: 300 women who wanted painless abortion were selected and were divided into two groups (150 cases in each group) by randomized digital tables from December 2018 to December 2020. Routine anesthesia induction was performed in these women. The women in the research group were given intravenous fluorbillofentones additionally before anesthesia induction. The hemodynamic indexes values, the dosages of sedative drugs used during abortion, and the rate of adverse reactions of the women were compared between the two groups. The levels of the coagulation index of the women in the two groups at 6h, 24h, and 48h were detected again. Results: The dosage of propofol (106.4±6.5mg) and times of propofol used (1.2±0.3 times) of the women in the research group during abortion were significantly lower than those (145.4±7.6mg and 2.1±0.5 times) of the women in the control group. The rate of excellent anesthesia efficacy (100.0%) of the women in the research group was significantly better than that (92.0%) of the women in the control group (all P<0.05). There were no significant differences in the coagulation indexes levels at postoperative 6h, 24h, and 48h of the women between the two groups (P>0.05). The values of heart rate and mean arterial pressure of the women in the research group before induction of anesthesia, at 5min after abortion began, at dilation of cervix uteri, at vacuum aspiration, at completion of surgery, and at 15min after abortion were significantly lower than those of the women in the control group. The value of oxyhemoglobin saturation of the women in the research group was significantly higher than that of the women in the control group. The total incidence of adverse reactions (7.3%) of the women in the research group was significantly lower than that (15.3%) of the women in the control group (all P<0.05). Conclusion: Fluorbilofen used as preemptive analgesia during painless abortion of women has good anesthesia effect, which can effectively reduce the dosage of sedative drugs used during abortion, and has little effect on the indicators of coagulation function and hemodynamic indicators of the women.