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| Influence of aspirin combined with Shengui yangxue tablets used as pre-pregnancy intervention of patients with positive anticardiolipin antibody and recurrent spontaneous abortion on their thrombosis occurrence and subsequent pregnancy |
| Maternal and Child Health Care Hospital of Guangdong Province, Guangzhou, Guangdong Province, 511400 |
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Abstract To observe the influence of aspirin combined with Shengui yangxue tablets used as pre-pregnancy intervention of patients with positive anticardiolipin antibody (ACA) and recurrent spontaneous abortion (RSA) on their thrombosis occurrence. Methods: 114 patients with positive ACA and RSA were selected and were randomly divided into two groups (57 cases in each group). The patients in the control group were given aspirin treatment, and the patients in the observation group were given treatment of aspirin combined with Shengui yangxue tablets. The conversion situations of ACA, lupus anticoagulant (LA), and anti-β2glycoprotein antibody (β2-GPI) of the patients after treatment were compared between the two groups. The values of coagulation index, such as D-dimer, platelet aggregation rate, activated partial thromboplastin time (APTT), the prothrombin time (PT), thrombin time (TT), and fibrinogen (FIB), and the values of hemorheology parameters, such as whole blood high shear viscosity, whole blood low shear viscosity, and plasma viscosity, and the values of uterine artery resistance index (RI) and the ratio of peak systolic velocity to end-diastolic end diastolic velocity (S/D) of the patients in the two groups before and after treatment were detected. Results: After treatment, the ratios of serum ACA negative conversion (86.0%) and β2-GPI (80.8%) of the patients in the observation group were significantly higher than those (63.2% and 58.7%) of the patients in the control group (P<0.05), but there was no significant difference in the ratio of LA negative conversion of the patients between the two groups (P>0.05). The values of APTT and PT of the patients in the observation group were significantly higher than those of the patients in the control group, while the D-dimer level, the platelet aggregation rate, and the values of whole blood high viscosity, whole blood low viscosity, and plasma viscosity of the patients in the observation group were significantly lower than those of the patients in the control group (P<0.05), and there was no significant difference in the TT level of the patients between the two groups (P>0.05). The uterine artery RI and S/D values of the patients in the observation group were significantly lower than those of the patients in the control group. The rate of successful pregnancy (73.7%) of the patients in the observation group was significantly higher than that (57.9%) of the patients in the control group, and the rate of the pregnancy again (7.1%) of the patients in the observation group was significantly lower than that (18.2%) of the patients in the control group (P<0.05). Conclusion: Aspirin combined with Shengui yangxue tablets used for adjuvant therapy of the patients with positive ACA and RSA is beneficial to improve their thrombosis, which can regulate uterine blood perfusion, improve the success rate of subsequent pregnancy, and can reduce the risk of re-abortion.
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