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Abstract Blood hypercoagulable state, or prethrombotic state, may lead to variety of blood changes, such as thrombosis. When thrombus occurs in endometrium, it will cause a variety of adverse pregnancy outcomes, and recurrent spontaneous abortion (RSA) is one of them. Antiphospholipid antibodies, genetic factors, and metabolic disorders all will cause the formation of endometrial thrombosis, which will lead to the reduction of endometrial receptivity, poor placental perfusion, and eventually abortion. Therefore, in addition to routine examination, a thorough assessment of immunological, genetic, and endocrine etiology will determine the pregnancy outcomes of the pregnant women. The combined treatment of intervening inflammatory factors and maintaining coagulation balance can improve the endometrial receptivity, so as to protect the fetus. This paper summarizes above problems.
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