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| Analysis of the correlation between the sperm DNA fragmentation index of men and the parameters of their conventional semen and sperm motility |
| International Peace Maternity and Child Health Hospital, Institute of Birth Defects and Rare Diseases, School of Medicine, Shanghai Jiao Tong University; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, 200030 |
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Abstract To explore the correlation between the sperm DNA fragmentation index (DFI) of men and their age, conventional semen parameters, and sperm motility parameters. Methods: Sperm DFI, semen routine parameters, and sperm motility parameters of 616 men were detected. And these men were divided into three groups according to DFI values, which included DFI <15% group, 15%≤DFI<30% group, and DFI≥30% group. The correlations between the difference of parameters of conventional semen and sperm motility of the men in different groups and their sperm DFI were analyzed. Results: There were statistically significant differences in the forward motile sperm rate, the total number of motile sperm, the curve velocity (VCL), and linear velocity (VSL) of the men among different DFI groups (P<0.01). Sperm DNA fragmentation index of the men was positively correlated with their age and total number of motile sperm (r=0.35, r=0.27), and was negatively correlated with their total number of forward motile sperm and VCL (r=-0.42, r=-0.33). Conclusion: There is correlation between the sperm DFI of men and their age, some conventional semen parameters, and sperm motility parameters. Thus, sperm DFI combined with conventional semen parameters and sperm motility parameters can be used to synergy evaluate the sperm quality, to guide clinical treatment, and to predict the pregnancy outcomes after assisted reproduction.
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