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| Relationship between persistent high-risk human papilloma virus infection of the women and their vaginal microecological changes |
| The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, 215000 |
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Abstract To explore the changes of the vaginal microecology of the women with vulvar intraepithelial neoplasia（VIN) and cervical squamous intraepithelial lesion（SIL), and to analyze the relationship between persistent human papilloma virus（HPV) infection of the women and their vaginal microecology. Methods: The clinical data of 90 women with high risk HP infection who had undergone colposcopy biopsy from February 2018 to October 2020 were collected retrospectively. These women were divided into group A (30 cases with VIN), group B (30 cases with SIL), and group C (30 cases with normal cervical biopsy) according to the results of pathological examination of these women. All these women were followed up for 6 months after treatment, and were further divided into group D（27 cases with persistent HPV infection) and group E（63 cases with HPV negative conversion) according to whether their HPV infection converted to negative. All these women had undergone vaginal microecological examination at the time of enrolling in this study, and the differences of vaginal microecology of the women with different diseases status were analyzed. The differences of the vaginal microecology of the women with persistent HPV infection and the women with HPV negative conversion were analyzed. Logistic regression was used to analyze the possibly factors affecting the persistent HPV infection of the women. Results: The incidences of trichomoniasis vaginitis (TV), bacterial vaginosis (BV) and lactobacillus reduction of the women in group A and group B were significantly higher than those of the women in group C. The persistent infection rate of HPV of the women in group A, in group B, and in group C after 6 months followed up were 43.3%, 36.7%, and 10.0%, respectively, which had decreased gradually (P＜0.05). The incidences of TV, BV, and lactobacillus reduction of the women in group D were significantly higher than those of the women in group E (P＜0.05). The rate of the BV and lactobacillus decreased of the women were the risk factors of their persistent infection of HPV (P＜0.05). Conclusion: The women with VIN and SIL all have vaginal microecological imbalance, and the incidence of their persistent HPV infection is higher. The women with persistent infection of HPV have the vaginal microecological imbalance status, which is association with their BV occurrence and their lactobacillus reduction.
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