|
|
|
| Detections of serum inflammatory factors and coagulation function of pregnant women with intrahepatic cholestasis of pregnancy |
| Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University(Nanjing Maternal and Child Health Care Hospital), Nanjing, Jiangsu Province, 210000 |
|
|
|
|
Abstract To analyze the change of serum inflammatory factors and coagulation function of pregnant women with intrahepatic cholestasis of pregnancy(ICP). Methods: 95 pregnant women with ICP were selected in research group and were divided into group A(54 women with mild and moderate ICP) and group B(41 women with severe ICP) according to the severity of ICP from March 2019 to March 2020. In addition, 95 healthy pregnant women who underwent regular antenatal examination were selected in control group during the same period. The levels of serum inflammatory factors, such as interleukin-6(IL-6), interleukin-12(IL-12), and tumor necrosis factor-(TNF-), and the values of coagulation function indexes, such as thrombin time(TT), prothrombin time(PT), activated partial thromboplastin time(APTT), and fibrinogen(FIB) of the women in these groups were detected. Results: The levels of serum IL-6, IL-12, and TNF- of the women in the research group were 89.67±9.37, 58.61±7.34, and 63.74±8.23, respectively, which were significantly higher than those(35.29±6.17, 19.57±2.55, and 21.16±5.37, respectively) of the women in the control group. The values of TT, PT, APTT and FIB of the women in the research group were significantly higher than those of the women in the control group(all P<0.05). The levels of serum IL-6, IL-12, and TNF-, and the values of TT, PT, APTT and FIB of the women in group B were significantly higher than those of the women in group A(P<0.05). Conclusion: The levels of inflammatory factors of the pregnant women increase, and their coagulation functions are abnormal, and both of which get worse as the severity of ICP.
|
|
|
|
|
|
|
|
|
