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Abstract To investigate the effects of the brain natriuretic peptide (BNP) and the fetal fibronectin (FFN) levels of the pregnant women with hypertensive disorder complicating pregnancy on their microvascular injury and cardiac function. Methods: The healthy pregnant women (in control group) and the pregnant women with hypertensive disorder complicating pregnancy (in study group) from 2016 to 2018 were collected retrospectively. The women in the study group were divided into group A1 (women with gestational hypertension), group A2 (women with mild preeclampsia), and group A3 (women with severe preeclampsia) according to different severity of hypertensive disorder complicating pregnancy. The BNP and FFN levels, the indexes of microvascular injury and cardiac function indexes of the women were compared among these groups. The correlation between the BNP and FFN levels of the women and their indexes of microvascular injury and cardiac function was analyzed. Results: The BNP and FFN levels of the women in the study group were significant higher than those of the women in the control group, and the BNP and FFN levels of the women in group A3 were the highest, while those of the women in A1 group were the lowest (P＜0.01). The values of LVEF and E/A of the women in the control group, group A1, group A2, and group A3 had decreased in turn. The value of CO of the women in the control group, group A1, group A2, and group A3 had increased in turn. With the elevation of the blood pressure value of the women, their CO value increased, but their CI value decreased. The RFF value of the women in group A1, group A2, and group A3 were significant lower than that of the women in the control group, while the values of NO, vWF, and TM of the women were significant higher than those of the women in the control group (all P＜0.05). Conclusion: The levels of BNP and FFN of the pregnant women with hypertensive disorder complicating pregnancy are related to their microvascular damage and cardiac function. The higher of the levels of BNP and FFN, the more serious the microvascular injury and the worse the ventricular diastolic function.
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