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Abstract To investigate the expression of serum heat shock protein 70（HSP70) and the adverse pregnancy outcomes of pregnant women with preeclampsia. Methods: A total of 60 pregnant women with preeclampsia were selected, and were divided into group A（35 women with preeclampsia) and group B（25 women with severe preeclampsia) from October 2017 to October 2019. Another 40 healthy pregnant women who underwent regular physical examinations were selected in group C during the same period. The serum HSP70 levels of the women were compared among the three groups. And the relationship between the serum HSP70 levels of the women and their adverse pregnancy outcomes was analyzed. Results: The serum HSP70 level of the women in group B (5.47±2.16 ng/ml) was the highest, then followed by that（2.78±0.94 ng/ml）of the women in group A, and that (0.94±0.43 ng/ml) of the women in group C was the lowest (P<0.05). The incidence of the rate of fetal growth restriction, preterm delivery, postpartum hemorrhage, neonatal asphyxia, or fetal distress of the women in group B, in group A, and group C had decrease in turn significantly (all P<0.05). The incidence of the rate of fetal growth restriction, preterm delivery, postpartum hemorrhage, neonatal asphyxia, or fetal distress of the women with high level of serum HSP70 was significantly than that of the women with low level of serum HSP70 (P<0.05). Conclusion: The serum HSP70 level of the pregnant women with preeclampsia increases significantly, which increase as the disease worsen. The occurrences of adverse pregnancy outcomes of the women with high level of serum HSP70 also increase.
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