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| Value of the combined detection of D- dimer, activin-A, and progesterone levels for predicting early missed abortion |
| 1. Xuzhou Municipal Hospital affiliated Xuzhou Medical University, Jiangsu Province, 221000; 2. Xuzhou Clinical College, Xuzhou Medical Universit |
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Abstract To study the value of combined detection of D- dimer (D-D), activin-A (ACT-A), and progesterone (P) levels for predicting early missed abortion. Methods: 280 pregnant women during the first trimester of pregnancy were selected and were divided 40 women with missed abortion in observation group and 240 healthy pregnant women in control group from August 2018 to August 2020. The levels of blood D-D, ACT-A, and P during 6 gestational weeks of the women in the two groups were detected, and which of the women were compared between the two groups. ROC curve was used to analyze the predictive value of the levels of D-D, ACT-A, and P for missed abortion. Results: The level of D-D (2.65±1.11mg/L) of the women in the observation group was significantly higher than that (1.63±0.57 mg/L) of the women in the control group. The levels of ACT-A (207.61±56.54ng/L) and P (35.26±13.31nmol/L) of the women in the observation group were significantly lower than those (322.81±85.52 ng/L and 69.32±21.36 nmol/L) of the women in the control group (P<0.05). The AUC of D-D level, ACT-A level, and P level for predicting missed abortion were 0.805, 0.807, and 0.922, respectively. The AUC of the combined levels of D-D, ACT-A, and P for predicting missed abortion was 0.997, which had higher accuracy of predicting missed abortion. When the best critical value of the D-D level was ≥1.855 mg/L, the sensitivity and the specificity of the D-D level for predicting missed abortion were 77.5% and 70.4%, respectively. When the best critical value of the ACT-A level was ≤290.005 ng/L, the sensitivity and the specificity of the ACT-A level for predicting missed abortion were 52.1% and 100%, respectively. When the best critical value of the P level was ≤46.08 nmol/ L, the sensitivity and the specificity of the P level for predicting missed abortion were 91.3% and 80.0%, respectively. When the best critical value of the combination of the D-D level, the ACT-A level, and the P level was ≥1.855 mg/L, which sensitivity and specificity for diagnosing missed abortion were 97.5% and 99.2%, respectively. Conclusion: The combined detection of D-D, ACT-A and P levels has certain predictive value for missed abortion.
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