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| Effect of Guchong decoction for treating patients with abnormal uterine bleeding and its influence on the improvement of clinical symptoms and prognosis |
| 1.Taihe Hospital of Traditional Chinese Medicine Affiliated to Anhui Chinese Medical University, Fuyang, Anhui Province, 236600；2.Fuyang First Hospital Affiliated to Anhui Chinese Medical University |
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Abstract To explore the effects of the Guchong decoction plus or minus for treating patients with abnormal uterine bleeding on the improvement of their clinical symptoms and prognosis. Methods: A total of 102 patients with abnormal uterine bleeding who received outpatient treatment were selected and were divided into two groups (51 cases in each group) by bicolor sphere method from January 2021 to September 2023. The patients in the two groups were given dydrogesterone tablets for 6 menstrual cycles, and the patients in the study group were given Guchong decoction plus or minus additionally. The patients in both groups received 6 months of follow-up. The efficacy, the levels of the follicle stimulating hormone (FSH), estradiol (E2) and progesterone (P), the endometrial thickness, the rates of adverse reactions and abnormal uterine bleeding recurrence, and the prognostic quality of life of the patients were compared between the two groups. Results: The efficient rate (94.1%) of the patients in the study group after treatment was significantly higher than that (78.4%) of the patients in the control group. The E2 level of the patients in both groups had increased significantly and the levels of FSH and P of the patients in both groups had decreased significantly, and the variations of which of the patients in the study group were significantly more than those of the patients in the control group. The endometrium thickness of the patients in both groups had decreased significantly, and which (0.78±0.19cm) of the patients in the study group was significantly lower than that (1.09±0.24cm) of the patients in the control group. The incidence of adverse reactions (9.8%) of the patients in the study group was significantly lower than that (27.5%) of the patients in the control group, and the score of the Chinese version of world health organization quality of life scale (WHOQOLBREF) of the patients in both groups had increased significantly, and which (90.10±1.73 points) of the patients in the study group was significantly higher than that (84.56±2.95 points) of the patients in the control group. The recurrence rate of abnormal uterine bleeding (6.0%) of the patients in the study group was significantly lower than that (23.5%) of the patients in the control group (all P<0.05). Conclusion: Guchong decoction plus or minus for treating patients with abnormal uterine bleeding can significantly improve the clinical therapeutic effect, the sex hormone levels and the endometrial thickness, increase the prognosis quality of life and reduce the recurrence rate of abnormal uterine bleeding of the patients.
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