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| Analysis of detections of thyroid function and fetal free DNA level in peripheral blood of pregnant women with twin pregnancy |
| Rizhao People's Hospital, Shandong Province, 276800 |
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Abstract To explore the thyroid function and fetal free DNA level in peripheral blood of pregnant women with twin pregnancy. Methods: The pregnant women with twin pregnancy were selected and were divided 52 women with thyroid dysfunction in observation group and 52 women with normal thyroid function in control group from February 2019 to February 2020. The plasma genomic DNA magnetic bead method was used to extract and detect the fetal free DNA level in the peripheral blood of these women in the two groups. The blood glucose and blood lipid levels of the women in the two groups were detected by enzymic method. The incidences of gestational hypertension, anemia, and diabete of the women during pregnancy, and the fetal dysplasia and premature delivery were compared between the two groups. Results: The levels of fetal free DNA, total cholesterol, triglyceride, low density lipoprotein, cholesterol, and blood glucose of the women in the observation group were significantly higher than those of the women in the control group (P<0.05). There was no significant difference in the low-density lipoprotein level of the women between the two groups (P>0.05). The incidence (26.9%) of total complications, such as hypertension, anemia, diabetes, and fetal dysplasia of the women and the preterm birth rate (19.2%) in the observation group were significantly higher than those (11.5% and 1.9%) in the control group (P<0.05). Conclusion: The level of fetal free DNA in the peripheral blood of the women with twin pregnancy can reflect their thyroid function, blood glucose, and blood lipid levels. The women with twin pregnancy and dysfunction of thyroid function have more complications, and their pregnancy outcomes are not ideal.
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