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| Influence of embryo removed by tubal incision and suture combined with methotrexate for treating patients with tubal pregnancy on their incidences of intrauterine pregnancy and repeated tubal pregnancy after treatment |
| Liangxiang Teaching Hospital, Capital Medical University, Beijing, 102488 |
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Abstract To investigate the influence of embryo removed by tubal incision and suture combined with methotrexate for treating patients with tubal pregnancy on their incidences of natural pregnancy and repeated tubal pregnancy after treatment. Methods: From December 2013 to December, 480 patients with tubal pregnancy were included and were divided into study group and control group(240 cases in each group) according to random number table. The patients in the control group were given embryo removed by tubal incision and suture in order to tubal preservation, and the patients in the study group were given embryo removed by tubal incision and suture combined with methotrexate in order to tubal preservation. The tubal patency situation and the indicators relevant to clinic of the patients were compared between the two groups. After followed up for 1 year, the intrauterine pregnancy rate and repetitive tubal pregnancy situation of the patients were compared between the two groups. Results: After treatment, the complete tubal patency rate(57.9%) and partial tubal patency rate(40.0%) of the patients in the study group were significant higher than those(39.6% and 52.5%) of the patients in the control group, and the blood chorionic gonadotropin level of the patients in the study group when discharge, the time of hospital stay, the durations of abdominal pain and mass, and the menstrual recovery time of the patients in the study group were significant less than those of the patients in the control group(P<0.05). During the followed up for 1 year, the rate of intrauterine pregnancy(48.8%) of the patients in the study group was significant higher than that(30.4%) of the patients in the control group(P=0.000). There was no significant difference in the recurrence of tubal pregnancy(3.8% vs. 4.6%) of the patients between the two groups(P=0.648). The levels of estradiol, follicle stimulating hormone, and luteinizing hormone of the patients in the two groups had decreased significantly in 3 months after operation, but which of the patients had no significant difference between the two groups(P>0.05). There was no significant difference in the incidence of adverse reactions(5.4% vs. 4.6%) of the patients between the two groups(P=0.676). Conclusion: Embryo removed by tubal incision and suture combined with methotrexate for treating patients with tubal pregnancy can improve their tubal patency situation, increase the rate of natural pregnancy after treatment, reduce the rate of repeated tubal pregnancy without increasing the incidence of adverse reaction, which has high safety.
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