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| Effects of laparoscopic unilateral salpingectomy for treating patients with tubal pregnancy on their serum β-human chorionic gonadotropin and Netrin-1 levels and postoperative pregnancy |
| Ezhou Central Hospital, Ezhou, Hubei 436000 |
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Abstract To investigate the effects of laparoscopic unilateral salpingectomy for treating patients with tubal pregnancy on their serum β-human chorionic gonadotropin (β-hCG) and Netrin-1 levels and postoperative pregnancy. Methods: From January 2021 to November 2022, 40 patients with tubal pregnancy who underwent laparoscopic unilateral salpingectomy (in observation group) and 40 patients with tubal pregnancy who underwent laparoscopic unilateral fallopian tubal fenestration for removing the embryo (in control group) were selected in this study. The surgery-related indicators, the complications, the serum β-hCG and Netrin-1 levels before and after surgery and the postoperative ovarian reserve function indicators of the patients in the two groups were counted. The pregnancy status within 1 year after surgery of the patients in the two groups was followed up. Results: The intraoperative blood loss (72.1±4.8ml) of the patients in the observation group was significantly more than that (66.1±12.4ml) of the patients in the control group. The incidence of the postoperative complications (7.5%) and the rate of postoperative ectopic pregnancy (0) of the patients in the observation group were significantly lower than those (25.0% and 17.5%) of the patients in the control group. In 6 months after surgery, the serum luteinizing hormone level (6.15±1.12 mU/ml) of the patients in the observation group was significantly higher than that (5.63±0.95mU/ml) of the patients in the control group, and the anti-Mullerian hormone level (3.33±0.58 ng/ml) of the patients in the observation group was significantly lower than that (3.64±0.79 ng/ml) of the patients in the control group (all P<0.05). There were no significant differences in the
levels of β-hCG and Netrin-1 on the 3rd day after surgery and the time of the levels of β-hCG and Netrin-1 decreasing to normal after surgery of the patients between the two groups (all P>0.05). Conclusion: Laparoscopic unilateral salpingectomy and fallopian tubal fenestration for treating the patients with tubal pregnancy can effectively remove the ectopically implanted embryo. Compared with those of fallopian tubal fenestration, laparoscopic unilateral salpingectomy can reduce the postoperative complications and the risk of ectopic pregnancy again of the patients, but which has the risks of more intraoperative bleeding and damaging the ovarian reserve function of the patients.
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