Abstract To investigate nuchal translucency (NT) of the fetus by ultrasonography combined with serum placental growth factor (PLGF) and unconjugated estriol (uE3) of the women during 11-13 gestational weeks for screening Down's syndrome. Methods: The clinical data of 685 pregnant women who underwent screening for Down syndrome from October 2018 to October 2020 were selected retrospectively. Among them, 20 women with confirmed Down syndrome were in group A, and 665 normal pregnant women were in group B. Color Doppler ultrasound was used for NT examination of the fetus in both groups, and the PLGF and uE3 levels of the women in the two groups were detected. The diagnostic values of NT of the fetus and the PLGF and uE3 levels of the women for Down syndrome were evaluated. Results: The levels of serum PLGF (67.25±4.70pg /ml) and uE3 (0.89±0.20μg/L) of the women in group A were significant lower than those of the women in group B (112.15±8.35pg/ml and 1.90±0.42μg/L), and the thickness of NT (3.5±0.4mm) of the fetus in group A was significant more than that (1.8±0.4mm) of the fetus in group B. The serum PLGF level of the women during 11, 12, and 13 gestational weeks had decreased in turn, but the serum uE3 level of the women during 11, 12, and 13 gestational weeks had increased in turn. The serum PLGF and uE3 levels of high-risk pregnant women were significant lower than those of low-risk pregnant women, and the thickness of NT of the fetus of high-risk pregnant women was significant higher than that of low-risk pregnant women (P＜0.05). The sensitive and the accurate of serum PLGF and uE3 levels of the women combined with NT of the fetus by ultrasonography for screening Down syndrome were 93.3% and 94.0% (P＜0.05). Conclusion: The PLGF and UE3 levels of pregnant women with Down syndrome of the fetus are low, and the decreasing degree of PLGF and UE3 levels are related to the risk degree of the pregnant women and their gestational weeks. NT of the fetus by ultrasound combined with serum PLGF and UE3 levels of the women for screening Down syndrome during 11-13 gestational
weeks has high diagnostic accuracy.
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