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| The relationship between the expression of ARID1A and PIK3CA and the occurrence of ovarian cancer associated with endometriosis, and the risk factors |
| The Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, 067000 |
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Abstract To study the relationship between the expression rules of ARID1A and PIK3CA of the patients and the occurrence of their ovarian cancer associated with endometriosis, and to study the risk factors affecting the ovarian cancer of the patients their ovarian cancer associated with endometriosis. Methods: 85 patients with endometriosis selected as the research objects from January 2016 to may 2020, which included 45 patients with ovarian cancer associated with endometriosis in group A, 40 patients with endometriosis of ovarian in group B, and 80 patients without ovarian cancer associated with endometriosis in group C. The expression levels of ARID1A and PIK3CA of the patients were compared among the three groups. The diagnostic efficacy of the levels of ARID1A and PIK3CA of the patients for their endometriosis related ovarian cancer was analyzed, and the risk factors of endometriosis related ovarian cancer of the patients were also analyzed. Results: The expression levels of ARID1A and PIK3CA of the patients in group A were the highest, and then followed by those of the patients in group C, and those of the patients in group B were the lowest (P＜0.05). The sensitivity (97.8%) of the combined levels of ARID1A and PIK3CA of the patients for diagnosing endometriosis associated ovarian cancer was significant higher than that of ARID1A level or PIK3CA level alone. The critical values of ARID1A and PIK3CA expression levels were 44.56 and 40.06, respectively. Multivariate analysis had showed that older age, menopause, high level of follicle stimulating hormone, pelvic pain, abdominal discomfort, vaginal bleeding, and young age of menarche were the independent risk factors of the occurrence of ovarian cancer associated with endometriosis. Conclusion: The expressions of ARID1A and PIK3CA of the ovarian cancer associated with endometriosis of the patients increase. It suggests that the possible factors in clinical diagnosis and early intervention should be paid more attention to for improving the diagnosis rate of the ovarian cancer associated with endometriosis.
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