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| Blood characteristics of women with mild thalassemia during the third trimester of pregnancy and their influence on pregnancy outcomes |
| Wuxi Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, 214000 |
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Abstract To investigate the blood characteristics of the pregnant women with mild thalassemia, and to study its influence on the pregnancy outcomes. Methods: 55 pregnant women with mild thalassemia were selected in study group from January 2013 to July 2020, and 114 normal pregnant women were randomly selected in control group. The blood indexes during the third trimester of pregnancy (28 to 41 gestational weeks) of the women in the two groups were detected, and their pregnancy outcomes were analyzed. Results: The values of mean erythrocyte volume (MCV), mean erythrocyte hemoglobin volume (MCH), and hemoglobin (Hb) of the women in the study group were 70.67±1.10fl, 22.10±0.36pg, and 94.33±1.95g/L, respectively, which were significant lower than those (90.33±0.57fL， 29.81±0.24pg, and 118.33±1.18g/L, respectively) of the women in control group. The red blood cell count (RBC) of the women in the study group was 4.31±0.10×1012/L, which was significant higher than that (3.95±0.04×1012/L) of the women in the control group (P<0.01). The cesarean section rate (27.3%), neonatal weight (3016.9±82.2g), and macrosomia rate (1.8%) of the women in the study group were significant lower than those (55.3%, 3316.1±50.7g, and 10.5%) of the women in the control group. The Low birth weight ratio (12.7%), and blood transfusion during pregnancy rate (12.7%) of the women in the study group were significant higher than those (4.4% and 0.9%) of the women in the control group (P<0.05). There was no significant difference in perinatal complications rate of the women between the two groups (P>0.05). Regression analysis found that thalassemia of the women had no significant relevant to their pregnancy complications. Conclusion: Mild thalassemia does not increase the incidence of pregnancy complications of women during pregnancy, but it does increase the risk of low birth weight.
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