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| Correlation between urinary phthalate metabolites level of pregnant women and their gestational diabetes mellitus and glucose tolerance |
| 1. Longhua District Maternal and Child Health Care Hospital, Shenzhen, Guangdong Province, 518110；2. Longhua District People's Hospital, Shenzhen |
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Abstract To investigate the relationship between urinary phthalate metabolites level of pregnant women and their gestational diabetes mellitus (GDM) and glucose tolerance. Methods: A total of 85 pregnant women with GDM (in group A), 128 pregnant women with impaired glucose tolerance (in group B), and 50 pregnant women with normal glucose tolerance (in group C) were enrolled in this study from January 2019 to December 2020. The levels of monomethyl phthalate (MMP), mono-butyl phthalate (MBP), mono- (2-ethylhexyl) phthalate (MEHP), mono- (2-ethyl-5-oxohexyl) phthalate (MEOHP), and serum fasting blood glucose (FBG) of the women were compared among three groups. Spearman test and Logistic model were used to analyze the relationship between the levels of the four types of phthalate metabolites of the women and their GDM occurrence. The relationship between the levels of the four types of phthalate metabolites of the women and their FBG level was analyzed by multiple stepwise regressions. Results: The levels of MMP, MBP, MEHP, MEOHP, and FBG of the women in group A were the highest, followed by those of the women in group B, and which of the women in group C were the lowest (P＜0.05). The levels of MMP, MBP, MEHP, and MEOHP of the pregnant women were positively correlated with their GDM occurrence, and the increasing of the four types of phthalate metabolites were the risk factors of GDM and were the influence factors of FBG level of the pregnant women with GDM (all P＜0.05). Conclusion: The phthalate metabolites levels in the urine of the pregnant women are closely related to their GDM occurrence and glucose tolerance. The increased levels of MMP, MBP, MEHP, and MEOHP of the pregnant women may increase the risk of their GDM occurrence, so the pregnant women should reduce the exposure to phthalate.
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