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| Effects of ropivacaine combined with sufentanil epidural anesthesia during cesarean section on the maternal blood pressure and fetal internal milieu |
1.The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, 637000；2.Nanchong Central Hospital of Sichuan |
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Abstract To study the effects of ropivacaine combined with sufentanil epidural anesthesia during cesarean section on the maternal blood pressure and fetal internal milieu. Methods: A total of 104 pregnant women who wanted cesarean section were enrolled in this study between September 2017 and October 2020. All these women were given patient controlled epidural analgesia (PCEA) and were divided into group A (50 cases accepted ropivacaine alone for analgesia) and group B (54 cases accepted ropivacaine mixed with sufentanil for analgesia) according to the dosage regimen of analgesia. The blood pressure, the pain scores, the analgesia situation of the women, and the levels of fetal internal milieu related indicators at different time points were compared between the two groups. The maternal adverse reactions related to analgesia were recorded. Results: There were significant differences in the interaction effects of time between groups (P＜0.05). The systolic and diastolic blood pressure values of the women in group B at skin incision (T2) and fetal delivery (T3) were significant higher than those of the women in group A (P＜0.05). The proportion of anesthesia grade 1 (77.8%) of the women in group B was significant higher than that (62.0%) of the women in group A (P＜0.05). There was no significant difference in visual analog pain score (VAS) of the women when operating room leaved and 12 hours after surgery between the two groups (P＞0.05). The onset time of pain sensation block, duration of analgesia, and VAS scores in 2 hours and 6 hours after surgery of the women in group B were significant lower than those of the women in group A (P＜0.05). There were no significant differences in the values of fetal pH, PO2, and PCO2, the levels of serum potassium, sodium, and calcium and the total incidence of adverse reactions(12.0% vs.3.7%) of the women between the two groups (all P＞0.05). Conclusion: Ropivacaine combined with sufentanil epidural anesthesia during cesarean section has good anesthetic and analgesic effects, which can better prevent the occurrence of maternal hypotension without significant influence on fetal internal milieu.
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