|
|
|
| Correlation of the blood flow parameters of umbilical artery and the levels of serum total bile acid and cholylglycine of pregnant women with intrahepatic cholestasis of pregnancy and their neonatal lung injury occurrence |
| The Ninth People’s Hospital of Hangzhou, Zhejiang Province, 311225; 2.Shaoxing Maternal and Child Health Care Hospital |
|
|
|
|
Abstract To investigate the correlation between the blood flow parameters of umbilical artery and the levels of serum total bile acid（TBA) and cholylglycine（CG) of pregnant women with intrahepatic cholestasis of pregnancy（ICP) and their neonatal lung injury（ALI) occurrence.Methods：113 pregnant women with ICP were selected as study subjects from March 2017 to September 2020.According to the occurrence of ALI, these women were divided into group A（women without ALI) and group B（women with ALI).The women in group B were further divided into group B1（newborns with Transient Hyperrespiratory syndrome) and group B2（newborns with respiratory distress syndrome).The blood flow parameters of umbilical artery were measured by ultrasound, and the levels of TBA and CG were measured by enzyme circulation.Results: The proportion of severe ICP, serum TBA and CG levels, and the values of S/D and RI of umbilical blood flow of the women in group B were all significant higher than those of the women in group A（P<0.001), and there was no significant difference in the PI value of umbilical blood flow of the women between the two groups（P>0.05).The serum levels of TBA and CG, and the RI value of umbilical artery of the women in B2 group were significant higher than those of the women in group B1（P<0.05), while the S/D and PI values of umbilical artery of the women had no significant different between group B1 and group B2（P>0.05).Severe ICP, serum TBA and CG levels, and umbilical artery RI value were the independent risk factors of ALI, and serum TBA and CG levels were the independent risk factors of respiratory distress syndrome（P<0.05).TBA+RI, CG+RI, and TBA+CG all had some value for predicting ALI（P<0.05).Conclusion: The incidence of neonatal ALI in ICP pregnant women is related to their umbilical artery RI value, and their serum TBA and CG levels.The combination of umbilical artery RI value, and serum TBA and CG levels of the pregnant women has some predictive value for ALI.
|
|
|
|
|
|
|
|
|
